Evidence map›Paper›PMID 35093713›Full record

ArticleJournal of the mechanical behavior of biomedical materials2022

Predicting the micromechanics of embedded nerve fibers using a novel three-layered model of mouse distal colon and rectum.

Yunmei Zhao, Bin Feng, David M Pierce

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yunmei ZhaoDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Bin FengDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
David M PierceDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. Electronic address: dmpierce@engr.uconn.edu.
University of Connecticut · US

Funding

Determining the topology and molecular profiles of nociceptive DRG neurons innervating distal colon and rectumU01NS113873 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2021
$2.0M
The Role of Lumbar Splanchnic Innervations in Visceral Nociception and PainR01DK120824 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2023
$2.0M
NIDDK NIH HHS R01 DK120824NINDS NIH HHS U01 NS113873
6 · The paper itself

Abstract

Mechanotransduction plays a central role in evoking pain from the distal colon and rectum (colorectum) where embedded sensory nerve endings convert micromechanical stresses and strains into neural action potentials. The colorectum displays strong through-thickness and longitudinal heterogeneity with collagen concentrated in the submucosa thus indicating the significant load-bearing role of this layer. The density of sensory nerve endings is also significantly the greatest in the submucosa, suggesting a nociceptive function. Thus biomechanical heterogeneity in the colorectum influences the micromechanical stresses and strains surrounding afferent endings embedded within different layers of the colorectum which is critical for the mechanotransduction of various mechanical stimuli. In this study we aimed to: (1) calibrate and validate a three-layered computational model of the colorectum; (2) predict intra-tissue distributions of stresses and strains during mechanical stimulation of the colorectum ex vivo (i.e. circumferential stretching, punctuate probing, and mucosal shearing); and (3) establish a methodology to calculate local micromechanical stresses and strains surrounding afferent nerve endings embedded in the colorectum. We established three-layered FE models that include mucosa, submucosa, and muscular layers, and incorporated residual stretches, to calculate intra-tissue stresses and strains when the colorectum undergoes the mechanical stimuli used to characterize afferent neural encoding ex vivo. Finally, we established a methodology for detailed calculations of the local micromechanical stresses and strains surrounding afferent endings embedded in the colorectum and demonstrated this with a representative example. Our novel methodologies will bridge the existing neurophysiological and biomechanical evidence from experiments to advance our mechanistic understanding of colorectal mechanotransduction.

Indexed as

Mechanotransduction, CellularRectumAnimalsColonMiceNerve FibersPelvisColorectumFinite element modelingMechanotransductionMicromechanicsNerve fiberThree-layered model

Identifiers

PMID35093713
PMCPMC8916824
OpenAlexW4205736166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.