ArticleGenomics, proteomics & bioinformatics2022
Variation of the Vaginal Microbiome During and After Pregnancy in Chinese Women.
Article in Genomics, proteomics & bioinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 35 citations in OpenAlex.
- Vaginal Microbiota and Pelvic Floor Dysfunction: Mechanistic Insights and Therapeutic Implications.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- A microbiota-host axis mediates prostaglandin sensitivity: Lactobacillus crispatus as a biomarker and regulator of human labor induction.NPJ biofilms and microbiomes · 2026Article
- Beyond community state types: vaginal microbial diversity and CST-IV signatures are associated with pregnancy in euploid embryo transfer cycles.Frontiers in endocrinology · 2026Article
- Vaginal microbiome and preterm birth: Composition, mechanisms and microbiota‑directed therapies (Review).International journal of molecular medicine · 2025Review
- Microbial regulators of physiological and reproductive health in women of reproductive age: their local, proximal and distal regulatory roles.NPJ biofilms and microbiomes · 2025Review
- The Impact of Lifestyle on Reproductive Health: Microbial Complexity, Hormonal Dysfunction, and Pregnancy Outcomes.International journal of molecular sciences · 2025Review
- Analysis of risk factors and prediction model construction for poor healing of perineal wounds after vaginal delivery: A retrospective case-control study.International journal of nursing studies advances · 2025Article
- Metagenomic analysis reveals the novel role of vaginal Lactobacillus iners in Chinese healthy pregnant women.NPJ biofilms and microbiomes · 2025Article
- Correlation between Escherichia coli infection during pregnancy and maternal-fetal outcomes: a retrospective analysis.BMC infectious diseases · 2025Article
- Article
- The Role of the Vaginal Microbiome in Immune Modulation in Cervical Cancer: Composition, Molecular Mechanisms, and Therapeutic Potential.Clinical Medicine Insights. Oncology · 2025Review
- A pilot study of cervicovaginal microbiome patterns associated with embryo implantation outcomes in endometriosis-associated infertility.Frontiers in medicine · 2025Article
- Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies.Genomics, proteomics & bioinformatics · 2024Review
- MAMI: a comprehensive database of mother-infant microbiome and probiotic resources.Nucleic acids research · 2024Article
- Fecal and vaginal microbiota of vaccinated and non-vaccinated pregnant elk challenged withFrontiers in veterinary science · 2024Article
- Alterations of the paired maternal vaginal microbiome and neonatal meconium microbiome in vulvovaginal candidiasis positive pregnant women.Frontiers in cellular and infection microbiology · 2024Article
- Vaginal and Rectal microbiome changes following administration of a multi-species antenatal probiotic: A randomized control trial.Gut microbes reports · 2024Article
- Microbiome structure in healthy and pregnant women and importance of vaginal dysbiosis in spontaneous abortion.Frontiers in cellular and infection microbiology · 2024Review
- Association between vaginal microbiome alteration and povidone iodine use during delivery.BMC microbiology · 2023Article
- Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care.Protein & cell · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A comprehensive profiling of the vaginal microbial communities and their variability enables an accurate description of the microbiome in women. However, there is a lack of studies available on Chinese women. In the present study, the composition of the vaginal microbiota during pregnancy and the 6-week postpartum period of 454 Chinese women was characterized by sequencing the V3-V4 region of the 16S ribosomal RNA (rRNA) gene. The vaginal microbiome showed variations during pregnancy and the postpartum period based on the abortion history, hypertensive disorders, delivery mode, and maternal age. Co-variation of 22 bacterial taxa, including the Lactobacillus genus and two of its species, may account for the common characteristics of the vaginal microbiome under scenarios of different medical histories and pregnancy outcomes. In contrast, discriminant bacterial species were significantly different between women who had preterm birth (PTB) with and without premature rupture of membranes (PROM), and the community state type (CST) IV-A without any predominant Lactobacillus species in the microbiota was more prevalent during pregnancy in the PROM-PTB cases, suggesting that specific bacterial species could be considered to distinguish between different types of PTB. By providing data on Chinese women, this study will enrich the knowledge of the human microbiome and contribute to a better understanding of the association between the vaginal microbiome and reproductive health.
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