ArticleNeuroImage2022
Effects of transcranial alternating current stimulation on spiking activity in computational models of single neocortical neurons.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of Extracellular Resistance on Neuronal Sensitivity Under Weak Alternating Electric Field Stimulation: A Computational Study.Biomimetics (Basel, Switzerland) · 2026Article
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem.PLoS computational biology · 2025Article
- Multi-scale model of neural entrainment by transcranial alternating current stimulation in realistic cortical anatomy.Journal of computational neuroscience · 2025Article
- Computational Models of High-Definition Electroconvulsive Therapy for Focal or Multitargeting Treatment.The journal of ECT · 2025Article
- Effects of transcranial alternating current stimulation on Spike train correlation in two-compartment model neurons.Biological cybernetics · 2025Article
- Phase-lagged tACS between executive and default mode networks modulates working memory.Scientific reports · 2025Article
- μ-Transcranial Alternating Current Stimulation Induces Phasic Entrainment and Plastic Facilitation of Corticospinal Excitability.The European journal of neuroscience · 2025Article
- Effects of dendritic CaJournal of computational neuroscience · 2025Article
- Inkjet-printed transparent electrodes: Design, characterization, and initial in vivo evaluation for brain stimulation.PloS one · 2025Article
- Morphological variability may limit single-cell specificity to electric field stimulation.Frontiers in synaptic neuroscience · 2025Article
- The effect of brain tissue anisotropy on the electric field caused by transcranial electric stimulation: Sensitivity analysis and magnetic resonance electrical impedance tomography.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Phase-synchronized 40 Hz tACS and iTBS effects on gamma oscillations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Transsynaptic modulation of cerebellar nuclear cells: theta AC-burst stimulation.Journal of neural engineering · 2024Article
- Frequency-domain analysis of membrane polarization in two-compartment model neurons with weak alternating electric fields.Cognitive neurodynamics · 2024Article
- Induced neural phase precession through exogenous electric fields.Nature communications · 2024Article
- Induced neural phase precession through exogeneous electric fields.bioRxiv : the preprint server for biology · 2023Article
- Intensity- and frequency-specific effects of transcranial alternating current stimulation are explained by network dynamics.bioRxiv : the preprint server for biology · 2023Article
- Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS).PLoS computational biology · 2023Article
- Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation.Trends in cognitive sciences · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neural oscillations are a key mechanism for information transfer in brain circuits. Rhythmic fluctuations of local field potentials control spike timing through cyclic membrane de- and hyperpolarization. Transcranial alternating current stimulation (tACS) is a non-invasive neuromodulation method which can directly interact with brain oscillatory activity by imposing an oscillating electric field on neurons. Despite its increasing use, the basic mechanisms of tACS are still not fully understood. Here, we investigate in a computational study the effects of tACS on morphologically realistic neurons with ongoing spiking activity. We characterize the membrane polarization as a function of electric field strength and subsequent effects on spiking activity in a set of 25 neurons from different neocortical layers. We find that tACS does not affect the firing rate of investigated neurons for electric field strengths applicable to human studies. However, we find that the applied electric fields entrain the spiking activity of large pyramidal neurons and large basket neurons at < 1 mV/mm field strengths. Our model results are in line with recent experimental studies and can provide a mechanistic framework to understand the effects of oscillating electric fields on single neuron activity. They highlight the importance of neuron morphology and biophysics in responsiveness to electrical stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.