Evidence map›Paper›PMID 35093288›Full record

ReviewTrends in molecular medicine2022

Adaptive immune cell responses as therapeutic targets in antibody-mediated organ rejection.

Kevin Louis, Camila Macedo, Carmen Lefaucheur, Diana Metes

Open access · greenAbstract readReview
In one paragraph

Review in Trends in molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. High-dimensional profiling of immune responses to kidney transplant reveals heterogeneous T helper 1 and B cell effectors associated with rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  9. Article
  10. Characteristic changes in blood routine and peripheral blood lymphocyte subpopulations in recipients of different types of rejection.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  11. Activation and Regulation of Indirect Alloresponses in Transplanted Patients With Donor Specific Antibodies and Chronic Rejection.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Kevin LouisKidney Transplant Department, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Human Immunology and Immunopathology, Institut National de la Santé et de la Recherche Médicale UMR 976, Université de Paris, Paris, France.
Camila MacedoDepartment of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Carmen LefaucheurKidney Transplant Department, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Paris Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale UMR 970, Université de Paris, Paris, France.
Diana MetesDepartment of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: metesdm@upmc.edu.
University of Pittsburgh Medical Center · USAssistance Publique – Hôpitaux de Paris · FRTranslational Research in Oncology · FR

Funding

Diversity of TFH cells and DSA generation after kidney transplantationR01AI130010 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI METES, DIANA M · 2017 to 2021
$3.4M
Contribution of TFH and of TREG cells to DSA generation in sensitized KTx recipientsR21AI116746 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI METES, DIANA M · 2015 to 2016
$415k
NIAID NIH HHS R01 AI130010NIAID NIH HHS R21 AI116746
6 · The paper itself

Abstract

Humoral alloimmunity of organ transplant recipient to donor can lead to antibody-mediated rejection (ABMR), causing thousands of organ transplants to fail each year worldwide. However, the mechanisms of adaptive immune cell responses at the basis of humoral alloimmunity have not been entirely understood. In this review, we discuss how recent investigations have uncovered the key contributions of T follicular helper (T

Indexed as

Graft RejectionOrgan TransplantationAntibodiesGraft SurvivalHumansImmunity, HumoralAntibodiesalloimmunityB cellshumoral responseorgan transplantationT follicular helper cells

Identifiers

PMID35093288
PMCPMC8882148
OpenAlexW4210290456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.