ArticleJournal francais d'ophtalmologie2022
Cannabis smoking and glaucoma in the UK Biobank cohort.
Article in Journal francais d'ophtalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study.Scientific reports · 2023Pooled it
- Cannabis, Intraocular Pressure, and the Growth Arrest-Specific 7 (GAS7) Gene: A Retrospective Analysis.Cureus · 2022Article
- Identifying Modifiable Risk Factors for Glaucoma.Journal of current ophthalmologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCigarette smoking is a well-known risk factor for primary open-angle glaucoma (POAG). Tobacco smoke contains a variety of chemicals, including nicotine, free radicals, and carbon monoxide, all of which can play a role in the development of POAG. Cannabis smoke, like tobacco smoke, contains a comparable variety of carcinogenic and toxic compounds. In the present study, we analyzed UK Biobank data to determine whether smoking cannabis, like cigarettes, might be related to POAG.
methodsOur analysis included all subjects with glaucoma and cannabis smoking information. Data processing was performed on Minerva, a Linux mainframe with Centos 7.6, at the Icahn School of Medicine at Mount Sinai. We used the UK Biobank Data Parser (ukbb parser), a python-based package that allows easy interfacing with the large UK Biobank dataset. Statistical analysis was performed with SPSS 25 and R.
resultsSubjects who used cannabis 100 times or more were significantly younger (10years) when they developed glaucoma than subjects who never used cannabis. The effects of age (P<0.001) and cigarettes (P=0.014) on POAG incidence were significant, but the effect of cannabis use was not (P=0.662). The effect of cannabis use on age at glaucoma diagnosis was significant and unrelated to the effects on intraocular pressure or cigarette pack-years smoked. Analysis of intraocular pressure showed that mean pressures of subjects who used cannabis 11-100 times were significantly lower than those who took no cannabis.
conclusionInhaling cannabis smoke is injurious to the eye, but in the case of glaucoma the manifestations are different from those of inhaled tobacco smoke. Cannabis reduces intraocular pressure but accelerates glaucoma development. Cannabis does not increase risk of glaucoma. Cigarette smoking increases risk of glaucoma and significantly accelerates glaucoma development. Apparently, early use of cannabis leads to the earlier development of glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.