Evidence map›Paper›PMID 35093193›Full record

ReviewThe Lancet. Child & adolescent health2022

Childhood maltreatment and its role in the development of pain and psychopathology.

Mariesa Cay, Joseph Gonzalez-Heydrich, Martin H Teicher, Hanne van der Heijden, Dost Ongur, Ann K Shinn, Jaymin Upadhyay

Abstract readReview
In one paragraph

Review in The Lancet. Child & adolescent health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Neurodevelopmental considerations for transcranial magnetic stimulation trials in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariesa CayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Joseph Gonzalez-HeydrichDepartment of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Martin H TeicherDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA; Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA, USA.
Hanne van der HeijdenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Faculty of Science, Biomedical Sciences Neurobiology, University of Amsterdam, Amsterdam, Netherlands.
Dost OngurDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA; Schizophrenia and Bipolar Disorder Program, Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA.
Ann K ShinnDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA; Schizophrenia and Bipolar Disorder Program, Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA.
Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: jaymin.upadhyay@childrens.harvard.edu.

Funding

Randomized controlled trial of enhanced coordinated specialty care (CSC 2.0)P50MH115846 · NIMH · MCLEAN HOSPITAL · PI Dost Ongur · 2019 to 2026
$16.9M
Early Stress, Sensitive Periods and the Neurobiology of AddictionR01DA017846 · NIDA · MC LEAN HOSPITAL (BELMONT, MA) · PI TEICHER, MARTIN H · 2004 to 2024
$9.8M
Neurobiology of Mothering and Infant StressR01HD079484 · NICHD · MCLEAN HOSPITAL · PI BOSQUET ENLOW, MICHELLE A, GRANT, PATRICIA ELLEN · 2015 to 2019
$3.6M
Dissecting Central Mechanisms of Hypoalgesia in SchizophreniaR21MH122967 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI SHINN, ANN KYUNGAH, UPADHYAY, JAYMIN A · 2020 to 2020
$490k
Cerebro-cerebellar circuitry in the pathophysiology of auditory hallucinations: dysmetria of auditory perceptual processing?R21MH121831 · NIMH · MCLEAN HOSPITAL · PI LIU, HESHENG, SHINN, ANN KYUNGAH · 2019 to 2020
$451k
Eating worms: an unusual nicotinic acetylcholine receptor from the nematode pharynx as a potential drug targetR21AI121831 · NIAID · IOWA STATE UNIVERSITY · PI ROBERTSON, ALAN P · 2016 to 2017
$393k
NIAID NIH HHS R21 AI121831NICHD NIH HHS R01 HD079484NIDA NIH HHS R01 DA017846NIMH NIH HHS P50 MH115846NIMH NIH HHS R21 MH121831NIMH NIH HHS R21 MH122967NIMH NIH HHS RF1 MH122967
6 · The paper itself

Abstract

Childhood maltreatment represents a form of trauma capable of altering fundamental neurobiological properties and negatively impacting neurodevelopmental processes. An outcome of childhood maltreatment is the emergence of psychopathology, which might become evident during childhood or adolescence, but might also project into adulthood. In this Review, we propose a biobehavioural framework in which childhood maltreatment and the associated aberrant neurobiological mechanisms and behavioural processes additionally lead to the onset of altered pain processing and, ultimately, the existence of pain syndromes. Considering that subpopulations of maltreated children show preserved function and minimal psychiatric or pain symptoms, compensatory mechanisms-perhaps instilled by robust psychosocial support systems-are also discussed. We present validated tools and experimental methods that could facilitate better comprehension of the interactions between childhood maltreatment, psychopathology, and pain. Such tools and approaches can in parallel be implemented to monitor abnormal pain-related processes and potentially guide early intervention strategies in cases of childhood maltreatment.

Indexed as

AdolescentBiobehavioral SciencesChildChild AbuseChild, PreschoolHumansMental DisordersModels, NeurologicalPainPsychopathologySomatosensory Disorders

Identifiers

PMID35093193
PMCPMC10364973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.