Evidence map›Paper›PMID 35093182›Full record

ArticleActa neuropathologica communications2022

Targeting the A

Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A Jacobson, Dilip K Tosh, Shruti Dharmaraj, Susan A Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J Heijnen

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
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  7. Cognitive dysfunction in chemobrain: Molecular mechanisms and therapeutic implications.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Mitochondrial AThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Anand Kumar SinghDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rajasekaran MahalingamDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Silvia SquillaceDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Kenneth A JacobsonNational Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, 20892, USA.
Dilip K ToshNational Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, 20892, USA.
Shruti DharmarajDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Susan A FarrThe Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA.
Annemieke KavelaarsDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Daniela SalveminiDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Cobi J HeijnenDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. CJHeijnen@mdanderson.org.ORCID 0000-0002-1928-3050
The University of Texas MD Anderson Cancer Center · USNational Institutes of Health · USSaint Louis University · USSt. Louis VA Medical Center · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Validation of Fibroblast-Derived PI16 as a Novel Target for pain TreatmentR01NS116704 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHEPHERD, ANDREW JOHN · 2020 to 2024
$3.6M
A3AR agonists as a novel approach to mitigate chemotherapy induced neurotoxicityR01CA230512 · NCI · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA · 2018 to 2022
$2.8M
Mesenchymal Stem Cells to Repair ChemobrainR01CA208371 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIJNEN, COBI J, SHEPHERD, ANDREW JOHN · 2016 to 2020
$2.4M
PQ12 Targeting HDAC6 for Chemotherapy-Induced Neuropathy and ChemobrainR01CA227064 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRACE, PETER M, SHEPHERD, ANDREW JOHN · 2018 to 2023
$2.2M
A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathyR01CA169519 · NCI · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA · 2013 to 2017
$1.5M
Intramural NIH HHS ZIA DK031117NCI NIH HHS R01 CA169519NCI NIH HHS R01 CA208371NCI NIH HHS R01 CA227064NCI NIH HHS R01 CA230512NIH HHS CA208371NIH HHS CA227064NIH HHS RO1CA230512NIH HHS ZIADK31117NINDS NIH HHS R01 NS116704
6 · The paper itself

Abstract

Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities. We investigated the capacity of a highly selective A

Indexed as

Adenosine A3 Receptor AgonistsAnimalsAntineoplastic AgentsChemotherapy-Related Cognitive ImpairmentCisplatinFemaleMaleMiceMotor ActivityNeuronsOxidative StressPainReceptor, Adenosine A3Spatial MemoryAdenosine A3 Receptor AgonistsAntineoplastic AgentsCisplatinReceptor, Adenosine A3A3ARAdenosineChemotherapyCisplatinCognitive impairmentMechanical allodyniaPeripheral neuropathySensorimotor deficitSpontaneous pain

Identifiers

PMID35093182
PMCPMC8800287
OpenAlexW4210405243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.