Evidence map›Paper›PMID 35093173›Full record

ArticleStem cell research & therapy2022

LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4.

Hongwei Gao, Hui Dong, Jiachun Zheng, Xufeng Jiang, Mingzhi Gong, Le Hu, Jinshan He, Yongxiang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Long non-coding RNAWorld journal of stem cells · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hongwei Gao *Department of Orthopedics, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital, No.98 of Nantong West Road, Guangling District, Yangzhou, 225001, People's Republic of China.
Hui Dong *Department of Orthopedics, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital, No.98 of Nantong West Road, Guangling District, Yangzhou, 225001, People's Republic of China.
Jiachun ZhengDepartment of Trauma and Orthopedics, The Second Hospital, Cheeloo College of Medicine, Shandong University, No.247 of North Park Street, Jinan, 250033, People's Republic of China.
Xufeng JiangDepartment of Trauma and Orthopedics, The Second Hospital, Cheeloo College of Medicine, Shandong University, No.247 of North Park Street, Jinan, 250033, People's Republic of China.
Mingzhi GongDepartment of Trauma and Orthopedics, The Second Hospital, Cheeloo College of Medicine, Shandong University, No.247 of North Park Street, Jinan, 250033, People's Republic of China.
Le HuDepartment of Orthopedics, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital, No.98 of Nantong West Road, Guangling District, Yangzhou, 225001, People's Republic of China.
Jinshan HeDepartment of Orthopedics, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital, No.98 of Nantong West Road, Guangling District, Yangzhou, 225001, People's Republic of China.
Yongxiang WangDepartment of Orthopedics, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital, No.98 of Nantong West Road, Guangling District, Yangzhou, 225001, People's Republic of China. wyx918spine@126.com.ORCID 0000-0003-3763-7411
Northern Jiangsu People's Hospital · CNSecond Hospital of Shandong University · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) can differentiate into diverse cell types under specific conditions. Dysfunction in the osteogenic differentiation of MSCs can result in bone metabolism-related diseases, including osteoporosis. Accumulating evidence has revealed that long non-coding RNA (lncRNAs) play critical regulatory roles during MSC differentiation.

methodsIn the present study, we identified an evolutionarily conserved lncRNA expressed during the osteogenic differentiation of MSCs, which we termed LINC01119. We first identified LINC01119 as a negative regulator of the osteogenic differentiation of MSCs.

resultsLINC01119 knockdown markedly induced calcium deposition in bone marrow MSCs and promoted the osteogenic differentiation of MSCs. More importantly, we demonstrated the underlying molecular basis through which LINC01119 regulates osteogenesis via the Wnt pathway by targeting FZD4. Furthermore, we observed that transcription factor EBF3 could directly bind the promoter site of LINC01119.

conclusionsWe first explored the molecular regulatory mechanism of LINC01119 during the osteogenic differentiation of MSCs and revealed that LINC01119 negatively regulates osteogenesis through the Wnt pathway by targeting FZD4.

Indexed as

Mesenchymal Stem CellsOsteogenesisCell DifferentiationCells, CulturedGene Expression RegulationWnt Signaling PathwayFZD4LINC01119Mesenchymal stem cellOsteogenic differentiationWnt pathway

Identifiers

PMID35093173
PMCPMC8800246
OpenAlexW4210666929

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.