SynthesisMalaria journal2022
Plasmodium falciparum histidine-rich protein 2 and 3 genes deletion in global settings (2010-2021): a systematic review and meta-analysis.
Synthesis in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic accuracy of novel Biocredit species-specific LDH-based immunochromatographic assay for Plasmodium falciparum and Plasmodium vivax detection: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Global burden of asymptomatic malaria among blood donors: systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Malaria: a review on its current epidemiological status and management strategies.Malaria journal · 2026Review
- Molecular, Transcriptomic, and Proteomic Characterization ofmedRxiv : the preprint server for health sciences · 2026Article
- A comparison of the cost-effectiveness of the current standard of care and of the haematology analyser XN31-microscopy combination for diagnosing malaria in a nonendemic country.Memorias do Instituto Oswaldo Cruz · 2026Article
- Plasmodium falciparum Kelch13 Variants and Histidine-Rich Protein 2/3 Deletions in Central Ethiopia, 2023.The American journal of tropical medicine and hygiene · 2025Article
- The Diagnostic Performance of a Sysmex XN-31 Automated Malaria Analyzer vs. Expert Microscopy.International journal of laboratory hematology · 2025Article
- Estimating malaria antigen dynamics and the time to negativity of next-generation malaria rapid diagnostic tests.Malaria journal · 2025Article
- Genetic Characterization of Plasmodium falciparum Histidine-Rich Protein 2 Deletions and Their Impact on Malaria Interventions in Odisha, India.The American journal of tropical medicine and hygiene · 2025Article
- Voices from the Amazon: exploring implementor and user perceptions of non-invasive malaria diagnostics in Peru.Malaria journal · 2025Article
- Very low prevalence of Plasmodium falciparum histidine-rich protein 2 (pfhrp2) gene deletion in the Brazil, Venezuela, and Guyana tri-border.Scientific reports · 2025Article
- High Prevalence ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Review
- Molecular surveillance of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Mozambique, 2023.Malaria journal · 2024Article
- Plasmodium falciparum with pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria infections in the Lake Victoria region, Kenya.Tropical medicine and health · 2024Article
- A Countrywide Survey of hrp2/3 Deletions and kelch13 Mutations Co-occurrence in Ethiopia.The Journal of infectious diseases · 2024Article
- Novel Plasmodium falciparum histidine-rich protein 2/3 repeat type in Ethiopian malaria infection: does this affect performance of HRP2-based malaria RDT?Malaria journal · 2024Article
- High Frequency of Deletions in theTropical medicine and infectious disease · 2024Article
- Widespread pfhrp2/3 deletions and HRP2-based false-negative results in southern Ethiopia.Malaria journal · 2024Article
- Selective whole-genome sequencing ofmBio · 2024Article
- Factors influencing health workers' adherence to malaria treatment guidelines in under-five children in Nigeria: A scoping review.MalariaWorld journal · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe usefulness of histidine-rich protein-2/3 (HRP2/3)-based rapid diagnostic tests of malaria due to Plasmodium falciparum has been threatened by the appearance of mutant PfHRP2/3 genes. This study was undertaken to determine the global pooled estimates of PfHRP2/3gene deletions.
methodsRelevant publications were identified from electronic databases such as; PubMed, EMBASE, and MEDLINE online. Besides, all the relevant literatures were retrieved through Google and Google Scholar. STATA software was used for data analysis. The pooled estimates were calculated using random effect model. The summary estimates were presented using forest plots and tables.
resultsA total of 27 studies were included in the systematic review. However, only 24 and 17 studies were included for PfHRP2 and 3 gene deletion meta-analysis, respectively. The prevalence of PfHRP2 gene deletion across the individual studies ranged from the highest 100% to the lowest 0%. However, the meta-analysis result showed that the global pooled prevalence of PfHRP2 and PfHRP3 gene deletions were 21.30% and 34.50%, respectively. The pooled proportion of PfHRP2 gene deletion among false negative PfHRP2-based RDTs results was found to be 41.10%. The gene deletion status was higher in South America and followed by Africa. The pooled estimate of PfHRP2 gene deletion among studies, which did not follow the WHO PfHRP2/3 gene deletion analysis protocol was higher than their counter parts (21.3% vs 10.5%).
conclusionsThis review showed that there is a high pooled prevalence of PfHRP2/3 gene deletions in Plasmodium falciparum confirmed isolates and also a high proportion of their deletions among false-negative malaria cases using PfHRP2-based RDT results. Hence, malaria diagnosis based on PfHRP2-based rapid tests seems to be less sensitive and warrants further evaluation of PfHRP2/3 gene deletions.
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