Evidence map›Paper›PMID 35093073›Full record

ArticleJournal of nanobiotechnology2022

pH-responsive hierarchical H

Yue Zhang, Tianxiang Yue, Wenting Gu, Aidi Liu, Mengying Cheng, Hongyue Zheng, Dandan Bao, Fanzhu Li, Ji-Gang Piao

Registry-linked trialAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06725797 (Pilot Study on the Effectiveness of Sulphurous Thermal Water in Wound Hygiene), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06725797 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Pilot Study on the Effectiveness of Sulphurous Thermal Water in Wound Hygiene: Spa Wound Care

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2024 to 2024Enrolled30ConditionsUlcers, Wound - in Medical Care, Wounds and Injuries, Wound HealingArmswound hygiene with hypothermal sulfurous water by packs, wound hygiene with hypothermal sulfurous water by limb full immersion
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Nanomaterials: A Prospective Strategy for Biofilm-FormingInternational journal of nanomedicine · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yue Zhang *School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Tianxiang Yue *School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Wenting GuSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Aidi LiuSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Mengying ChengSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Hongyue ZhengLibraries of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Dandan BaoDepartment of Dermatology & Cosmetology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310053, People's Republic of China.
Fanzhu LiSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China. lifanzhu@zcmu.edu.cn.
Ji-Gang PiaoSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China. jgpiao@zcmu.edu.cn.

Funding

National Natural Science Foundation of China 81873014National Natural Science Foundation of China 82074027National Natural Science Foundation of China 82104405Natural Science Foundation of Zhejiang Province LZ21H280001Traditional Chinese Medicine Science and Technology Plan of Zhejiang Province 2021ZQ036Zhejiang Chinese Medical University School-level Scientific Research Fund Project 2020ZG21
6 · The paper itself

Abstract

backgroundMethicillin-resistant Staphylococcus aureus (MRSA) biofilm-associated bacterial infection is the primary cause of nosocomial infection and has long been an ongoing threat to public health. MRSA biofilms are often resistant to multiple antimicrobial strategies, mainly due to the existence of a compact protective barrier; thus, protecting themselves from the innate immune system and antibiotic treatment via limited drug penetration.

resultsA hierarchically structured hydrogen sulfide (H

conclusionICG-ZnS NPs combined with NIR laser irradiation exhibited significant anti-biofilm activity in MRSA biofilms, can accelerate the healing process through deep-penetration and anti-inflammatory effectuation. The proposed strategy has great potential as an alternative to antibiotic treatment when combating multidrug-resistant bacterial biofilms.

Indexed as

DisinfectantsMethicillin-Resistant Staphylococcus aureusWound InfectionAnti-Bacterial AgentsAnti-Inflammatory AgentsBiofilmsHumansHydrogen-Ion ConcentrationMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Inflammatory AgentsDisinfectantsAnti-biofilmGas therapyHydrogen sulfideHyperthermia therapyMRSAPenetrationZinc sulfide

Identifiers

PMID35093073
PMCPMC8800305

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.