Evidence map›Paper›PMID 35093007›Full record

Trial reportBMC infectious diseases2022

Association of cellular HIV-1 DNA and virological success of antiretroviral treatment in HIV-infected sub-Saharan African adults.

Desmorys Raoul Moh, Jean-Baptiste Ntakpé, Delphine Gabillard, Arlette Ahoubet Yayo-Emieme, Anani Badjé, Gérard M Kouame, Toni Thomas d'Aquin, Christine Danel, Xavier Anglaret, Serge P Eholié

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Desmorys Raoul MohUnité Pédagogique de Dermatologie et Infectiologie, UFR Sciences Médicales, Abidjan, Côte d'Ivoire. raoul.moh@pac-ci.org.
Jean-Baptiste NtakpéProgramme PAC-CI, 18 BP 1954, Abidjan 18, Côte d'Ivoire.
Delphine GabillardProgramme PAC-CI, 18 BP 1954, Abidjan 18, Côte d'Ivoire.
Arlette Ahoubet Yayo-EmiemeProgramme PAC-CI, 18 BP 1954, Abidjan 18, Côte d'Ivoire.
Anani BadjéProgramme PAC-CI, 18 BP 1954, Abidjan 18, Côte d'Ivoire.
Gérard M KouameProgramme PAC-CI, 18 BP 1954, Abidjan 18, Côte d'Ivoire.
Toni Thomas d'AquinCentre de Diagnostic et de Recherches sur le SIDA (CeDReS), CHU de Treichville, Abidjan, Côte d'Ivoire.
Christine DanelProgramme PAC-CI, 18 BP 1954, Abidjan 18, Côte d'Ivoire.
Xavier AnglaretProgramme PAC-CI, 18 BP 1954, Abidjan 18, Côte d'Ivoire.
Serge P EholiéUnité Pédagogique de Dermatologie et Infectiologie, UFR Sciences Médicales, Abidjan, Côte d'Ivoire.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHIV-1 DNA persists in infected cells, forming viral reservoirs. Pre-antiretroviral treatment (ART) HIV-1 DNA load was reported to predict ART success in European severely immunocompromised patients. The aim of this study was to determine whether HIV-1 DNA levels are associated with virological success in less severely immunocompromised patients who receive early ART in sub-Saharan Africa.

methodsThe association between pre-ART HIV-1 DNA and the virological response after 30 months on ART was studied in multivariate logistic regression in patients randomised to immediate ART groups in the Temprano trial, which assessed the benefits of early ART in HIV-infected adults in Côte d'Ivoire. HIV-1 DNA was quantified in peripheral blood mononuclear cell (PBMC) using real-time PCR.

resultsHIV-1 DNA levels were measured in 1013 patients. Their medians [IQR] of pre-ART CD4 count, HIV-1 RNA and HIV-1 DNA levels were 465 [379-578]/mm

conclusionLow HIV-1 DNA was statistically associated with virological success in this population of sub-Saharan African adults who started treatment with a median pre-ART CD4 count at 465/mm

Indexed as

HIV-1HIV InfectionsAfrica South of the SaharaDNA, ViralHumansLeukocytes, MononuclearDNA, ViralAfricaHIV-1 DNATest and treatTherapeutic success

Identifiers

PMID35093007
PMCPMC8800335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.