Evidence map›Paper›PMID 35092884›Full record

ReviewCancer genetics2022

The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer.

Julio C Ricarte-Filho, Stephen Halada, Alison O'Neill, Victoria Casado-Medrano, Theodore W Laetsch, Aime T Franco, Andrew J Bauer

Open access · greenAbstract readReview
In one paragraph

Review in Cancer genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Molecular and clinicopathological characteristics ofHistology and histopathology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. JCO precision oncology · 2025
    Observational
  12. Article
  13. Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Julio C Ricarte-FilhoDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States.
Stephen HaladaDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States.
Alison O'NeillDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States.
Victoria Casado-MedranoDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States.
Theodore W LaetschDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, United States; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Aime T FrancoDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Andrew J BauerDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States. Electronic address: bauera@chop.edu.
Children's Hospital of Philadelphia · US

Funding

CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
RESEARCH AND MENTORING EXCELLENCE IN DIVERSE AND INCLUSIVE ENVIRONMENTR01CA214511 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI FRANCO, AIME T. · 2018 to 2023
$2.7M
NCI NIH HHS R01 CA214511NIGMS NIH HHS T32 GM008562
6 · The paper itself

Abstract

Although adult and pediatric papillary thyroid cancer (PTC) share similar oncogenic drivers, they differ in the pathological features and outcomes of the disease. In adults with PTC, the most frequent genetic alterations are mutually exclusive point mutations in BRAF

Indexed as

Proto-Oncogene Proteins B-rafThyroid NeoplasmsAdultChildGene FusionHumansIodine RadioisotopesMutationThyroid Cancer, PapillaryIodine RadioisotopesProto-Oncogene Proteins B-rafAdult thyroid cancerNTRK fusionOncogenePediatric

Identifiers

PMID35092884
PMCPMC8931989
OpenAlexW4206092198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.