Evidence map›Paper›PMID 35092640›Full record

ArticleCytometry. Part A : the journal of the International Society for Analytical Cytology2022

Expression of unique gene signature distinguishes TCRαβ

Chunfa Jie, Rizwan Ahmed, Abdel Rahim A Hamad

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. A distinct TCRiScience · 2026
    Article
  2. Distinguishing cell-cell complexes from dual lineage cells using single-cell transcriptomics is not trivial.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chunfa JieDepartment of Biochemistry and Nutrition, Des Moines University College of Osteopathic Medicine, Des Moines, Iowa, USA.ORCID 0000-0003-4838-5168
Rizwan AhmedDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abdel Rahim A HamadDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USDes Moines University Osteopathic Medical Center · US

Funding

Mechanisms of Fas Ligand Control of Insulitis in Autoimmune DiabetesR01AI099027 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HAMAD, ABDEL RAHIM · 2013 to 2017
$2.0M
NIAID NIH HHS R01 AI099027
6 · The paper itself

Abstract

Increasing evidence shows pathophysiological significance of rare immune cells, necessitating the need for reliable and proper methods for their detection and analysis. We have recently identified a new lymphocyte that coexpresses lineage markers of T- and B-cells including T cell receptor and B cell receptor (called dual expressers, DEs). Because of the peculiar phenotype of DEs, we used multiple techniques to authenticate their identity (fluorescence-activated cell sorting [FACS], scRNAseq, EBV cell lines, and imaging flow cytometry). In an recent article published in this journal, Burel and colleagues successfully detected DEs using FACS and imaging microscopy. Yet they claimed, based on the profile of what they called naturally occurring CD3

Indexed as

B-LymphocytesReceptors, Antigen, T-Cell, alpha-betaCD3 ComplexFlow CytometryLymphocytesT-LymphocytesCD3 ComplexReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID35092640
PMCPMC11549974
OpenAlexW4225078744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.