Evidence map›Paper›PMID 35092502›Full record

ArticleMedical oncology (Northwood, London, England)2022

A linkage between effectual genes in progression of CRC through canonical and non-canonical TGF-β signaling pathways.

Marzieh Shirin, Sajedeh Madadi, Noshad Peyravian, Zahra Pezeshkian, Leili Rejali, Masoumeh Hosseini, Afshin Moradi, Binazir Khanabadi, Ghazal Sherkat, Hamid Asadzadeh Aghdaei and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Marzieh Shirin *Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Sajedeh Madadi *Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Noshad PeyravianBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Zahra PezeshkianBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Leili RejaliBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Masoumeh HosseiniDepartment of Pathology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Afshin MoradiDepartment of Pathology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Binazir KhanabadiBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Ghazal SherkatMedicin Faculty of Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Hamid Asadzadeh AghdaeiBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 19875-17411, Tehran, Iran.
Ehsan Nazemalhosseini-MojaradGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Yaman Street, Chamran Expressway, 19857-17411, Tehran, Iran. Ehsanmojarad@gmail.com.ORCID http://orcid.org/0000-0001-8914-004X
Shahid Beheshti University of Medical Sciences · IRIslamic Azad University, Mashhad · IRResearch Institute for Endocrine Sciences · IR

Funding

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences 858Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences 988
6 · The paper itself

Abstract

Different molecular signaling pathways have been involved in the incidence and progression of CRC. We aimed to examine the correlation between eight candidate genes, including TFGβ, SMAD2, SMAD4, RhoA, EGFR, MAP2K1, MTA1, and LEF1 in the progression of colorectal cancer (CRC) and their association with clinicopathological variables and CRC patients prognosis. Immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) analysis 2

Indexed as

AdultAgedColorectal NeoplasmsDisease ProgressionErbB ReceptorsFemaleGene Expression RegulationHumansImmunohistochemistryMaleMiddle AgedPrognosisTransforming Growth Factor betaWnt Signaling PathwayYoung AdultEGFR protein, humanErbB ReceptorsTransforming Growth Factor betaColorectal cancerEGFRNon-canonicalSignalingTGF-βWNT

Identifiers

PMID35092502
OpenAlexW4210347428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.