Evidence map›Paper›PMID 35092295›Full record

ReviewNutrition reviews2022

Effects of nutrition and gestational alcohol consumption on fetal growth and development.

Vishal D Naik, Jehoon Lee, Guoyao Wu, Shannon Washburn, Jayanth Ramadoss

Open access · hybridAbstract readReview
In one paragraph

Review in Nutrition reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vishal D NaikDepartment of Obstetrics & Gynecology, C.S. Mott Center for Human Growth and Development, School of Medicine, Wayne State University, Detroit, Michigan, USA.
Jehoon LeeDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Guoyao WuDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Shannon WashburnDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Jayanth RamadossDepartment of Obstetrics & Gynecology, C.S. Mott Center for Human Growth and Development, School of Medicine, Wayne State University, Detroit, Michigan, USA.ORCID 0000-0002-9778-5224
Texas A&M University · USWayne State University · US

Funding

A Novel Mechanistic Framework for FASD Etiology.R01AA023520 · NIAAA · WAYNE STATE UNIVERSITY · PI RAMADOSS, JAYANTH · 2015 to 2024
$3.5M
ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCYR01HL151497 · NHLBI · WAYNE STATE UNIVERSITY · PI RAMADOSS, JAYANTH · 2021 to 2024
$1.5M
A Novel Platform for Maternal Alcohol Consumption ScreeningR21AA023035 · NIAAA · TEXAS A&M AGRILIFE RESEARCH · PI RAMADOSS, JAYANTH · 2015 to 2016
$421k
NHLBI NIH HHS R01 HL151497NIAAA NIH HHS R01 AA023520NIAAA NIH HHS R21 AA023035
6 · The paper itself

Abstract

Fetal alcohol exposure can lead to a range of developmental disorders, including impaired fetal growth and development of multiple organ systems. These disorders are grouped under the term fetal alcohol spectrum disorders (FASDs). Adequate nutrition and a conducive intrauterine environment are essential for healthy fetal development. Nutrient deficiencies resulting from inadequate maternal nutrient ingestion may be compounded by alcohol-induced altered nutrient metabolism, placental clearance, and malabsorption. Alcohol-induced alteration of the intrauterine environment is the main source of developmental deficits and nutritional insufficiencies can worsen the effects on fetal development. In this review, we discuss studies examining the collective and interactive effects of nutrition (specifically iron, selenium, vitamin A, thiamine, zinc, folate, vitamin B12, choline, and amino acids) relative to gestational alcohol consumption and its effects on fetal growth and development. We also summarize scientific reports that tested potential benefits of micronutrient supplementation in animal models of fetal alcohol spectrum disorders and in humans. In summary, the deleterious effects of alcohol exposure in relation to nutrient homeostasis further validate that avoidance of alcohol consumption during pregnancy is the most effective way to mitigate the teratogenic effects of alcohol.

Indexed as

Fetal Alcohol Spectrum DisordersAlcohol DrinkingAnimalsEthanolFemaleFetal DevelopmentHumansNutritional StatusPlacentaPregnancyEthanol

Identifiers

PMID35092295
PMCPMC9086808
OpenAlexW4205519793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.