ArticleInteractive cardiovascular and thoracic surgery2022
Risk factors for stroke after total aortic arch replacement using the frozen elephant trunk technique.
Article in Interactive cardiovascular and thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Current options and recommendations for the treatment of aortic arch diseases.Annals of cardiothoracic surgery · 2026Article
- Frozen elephant trunk technique in redo aortic arch surgery: a step-by-step approach.Annals of cardiothoracic surgery · 2026Article
- A Comprehensive Total Body Perfusion Strategy vs Conventional Techniques in Elective Aortic Arch Surgery: A Comparative Analysis.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Aortic reinterventions following reoperative frozen elephant trunk aortic arch replacement for the treatment of residual type A aortic dissection.JTCVS open · 2026Article
- Neurological complications post aortic arch surgery: a state of art review.Journal of cardiothoracic surgery · 2025Review
- Thoracic aortic aneurysm.Nature reviews. Disease primers · 2025Review
- Article
- Article
- Relation between uric acid and stroke in aortic dissection.Journal of thoracic disease · 2024Article
- Management of Non-A Non-B Aortic Dissection: A Narrative Review.Journal of cardiovascular development and disease · 2024Review
- Hybrid and Endovascular Management of Aortic Arch Pathology.Journal of clinical medicine · 2024Review
- Association of Bovine Arch Anatomy With Incident Stroke After Transcatheter Aortic Valve Replacement.Journal of the American Heart Association · 2024Article
- Article
- Treatment of right-sided aortic arch aneurysms with aberrant left subclavian artery with Kommerell's diverticulum using the frozen elephant trunk technique.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Cerebral Protection Strategies and Stroke in Surgery for Acute Type A Aortic Dissection.Journal of clinical medicine · 2023Review
- Partial Arch Replacement Using Common Trunk Perfusion in Type A Acute Aortic Dissection.Cureus · 2023Article
- Distal Aortic Failure Following the Frozen Elephant Trunk Procedure for Aortic Dissection.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to analyse risk factors for postoperative stroke, evaluate the underlying mechanisms and report on outcomes of patients suffering a postoperative stroke after total aortic arch replacement using the frozen elephant trunk technique.
methodsTwo-hundred and fifty patients underwent total aortic arch replacement via the frozen elephant trunk technique between March 2013 and November 2020 for acute and chronic aortic pathologies. Postoperative strokes were evaluated interdisciplinarily by a cardiac surgeon, neurologist and radiologist, and subclassified to each's cerebral territory. We conducted a logistic regression analysis to identify any predictors for postoperative stroke.
resultsOverall in-hospital was mortality 10% (25 patients, 11 with a stroke). A symptomatic postoperative stroke occurred in 42 (16.8%) of our cohort. Eight thereof were non-disabling (3.3%), whereas 34 (13.6%) were disabling strokes. The most frequently affected region was the arteria cerebri media. Embolism was the primary underlying mechanism (n = 31; 73.8%). Mortality in patients with postoperative stroke was 26.2%. Logistic regression analysis revealed age over 75 (odds ratio = 3.25; 95% confidence interval 1.20-8.82; P = 0.021), a bovine arch (odds ratio = 4.96; 95% confidence interval 1.28-19.28; P = 0.021) and an acute preoperative neurological deficit (odds ratio = 19.82; 95% confidence interval 1.09-360.84; P = 0.044) as predictors for postoperative stroke.
conclusionsStroke after total aortic arch replacement using the frozen elephant trunk technique remains problematic, and most lesions are of embolic origin. Refined organ protection strategies, and sophisticated monitoring are mandatory to reduce the incidence of postoperative stroke, particularly in older patients presenting an acute preoperative neurological deficit or bovine arch.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.