ArticleMagnetic resonance in medicine2022
Accelerating joint relaxation-diffusion MRI by integrating time division multiplexing and simultaneous multi-slice (TDM-SMS) strategies.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- Diffusion tensor magnetic resonance imaging of the normal fetal lung: a preliminary report.Pediatric radiology · 2026Article
- Accelerated multi-shell diffusion MRI with Gaussian process estimated reconstruction of multi-band imaging.Magnetic resonance in medicine · 2025Article
- Multimodal MRI changes associated with non-motor symptoms of rapid eye movement sleep behaviour disorder in Parkinson's disease patients.Neuroradiology · 2025Article
- Maximum-entropy and subspace methods for high-resolution relaxation-diffusion distribution estimation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Time-division multiplexing (TDM) sequence removes bias in TMagnetic resonance in medicine · 2024Article
- Time-division multiplexing (TDM) sequence removes bias in T2 estimation and relaxation-diffusion measurements.bioRxiv : the preprint server for biology · 2024Article
- State-of-the-art magnetic resonance imaging sequences for pediatric body imaging.Pediatric radiology · 2023Review
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6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo accelerate the acquisition of relaxation-diffusion imaging by integrating time-division multiplexing (TDM) with simultaneous multi-slice (SMS) for EPI and evaluate imaging quality and diffusion measures.
methodsThe time-division multiplexing (TDM) technique and SMS method were integrated to achieve a high slice-acceleration (e.g., 6×) factor for acquiring relaxation-diffusion MRI. Two variants of the sequence, referred to as TDM3e-SMS and TDM2s-SMS, were developed to simultaneously acquire slice groups with three distinct TEs and two slice groups with the same TE, respectively. Both sequences were evaluated on a 3T scanner with in vivo human brains and compared with standard single-band (SB) -EPI and SMS-EPI using diffusion measures and tractography results.
resultsExperimental results showed that the TDM3e-SMS sequence with total slice acceleration of 6 (multiplexing factor (MP) = 3 × multi-band factor (MB) = 2) provided similar image intensity and microstructure measures compared to standard SMS-EPI with MB = 2, and yielded less bias in intensity compared to standard SMS-EPI with MB = 4. The three sequences showed a similar positive correlation between TE and mean kurtosis (MK) and a negative correlation between TE and mean diffusivity (MD) in white matter. Multi-fiber tractography also shows consistency of results in TE-dependent measures between different sequences. The TDM2s-SMS sequence (MP = 2, MB = 2) also provided imaging measures similar to standard SMS-EPI sequences (MB = 2) for single-TE diffusion imaging.
conclusionsThe TDM-SMS sequence can provide additional 2× to 3× acceleration to SMS without degrading imaging quality. With the significant reduction in scan time, TDM-SMS makes joint relaxation-diffusion MRI a feasible technique in neuroimaging research to investigate new markers of brain disorders.
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