ArticleAging clinical and experimental research2022
The association between serum soluble klotho levels and abdominal aorta calcification in older adults.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification.Scientific reports · 2026Article
- Association between serum Klotho levels and hypothyroidism in older adults: NHANES 2007-2012.Scientific reports · 2024Article
- The Association of Obesity and the Antiaging Humoral Factor Klotho in Middle-Aged and Older Adults.TheScientificWorldJournal · 2022Article
- The controversy of klotho as a potential biomarker in chronic kidney disease.Frontiers in pharmacology · 2022Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mutation of the mouse klotho gene leads to a syndrome resembling aging including calcification of the aorta.
objectiveTo examine the relationship between serum soluble klotho levels and abdominal aorta calcification (AAC) in subjects aged 60-79 years.
methodsThe National Health and Nutrition Examination Survey data were analyzed using logistic regression models to examine the independent association between soluble klotho tertile levels and the Kauppila AAC-24 score.
resultsA total of 1042 participants with a median klotho level of 796 pg/ml comprised the study sample. Overall, the prevalence of AAC was 39.2% and severe AAC was seen in 15.6% subjects. Participants with klotho levels ≤ 700 pg/ml were twice as likely (OR 2.21 (95% CI 1.15-4.26) to have severe AAC than their counterparts with klotho levels ≥ 906 pg/ml.
conclusionsSoluble klotho levels were inversely associated with severe AAC in older adults.
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Registered trials
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