Evidence map›Paper›PMID 35091881›Full record

ReviewReviews in endocrine & metabolic disorders2022

Vitamin D regulation of immune function during covid-19.

Daniel D Bikle

Open access · hybridAbstract readReview
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Daniel D BikleVeterans Affairs Medical Center and University of California San Francisco, 4150 Clement Street (111N), San Francisco, CA, 94121, USA. Daniel.bikle@ucsf.edu.
University of California, San Francisco · US

Funding

Role of IGF-I/integrin signaling in the periosteal response to loadR01AR055924 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BIKLE, DANIEL DAVID · 2008 to 2019
$3.5M
Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and functionI01BX003814 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2018 to 2021
–
BLRD VA I01 BX003814NIAMS NIH HHS R01 AR055924
6 · The paper itself

Abstract

Covid-19 has to date infected a confirmed 275 million people with 5.4 million, now dead, with the count rising every day. Although the virus, SARS-CoV2, causing Covid-19 infects many cells in the body, its infection of the upper and lower respiratory tract (upper airway epithelia and pulmonary alveolar pneumocytes and macrophages) causing what is now called a cytokine storm in the lungs is the major cause of morbidity and mortality. This results from a dysregulation of the innate immune system with an outpouring of proinflammatory cytokines and chemokines leading to abnormal activation of the adaptive immune pathway. Airway epithelia constitutively expresses CYP27B1, the enzyme producing the active vitamin D metabolite, 1,25(OH)

Indexed as

COVID-19Vitamin DHumansImmunity, InnateRNA, ViralSARS-CoV-2RNA, ViralVitamin DAdaptive immunityAirway epitheliaCalcitriolCathelicidinInnate immunityPulmonary alveolar macrophageViral infectionVitamin D

Identifiers

PMID35091881
PMCPMC8799423
OpenAlexW4210545444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.