Evidence map›Paper›PMID 35091836›Full record

ArticlePediatric nephrology (Berlin, Germany)2022

Development and autoregulation of kidney function in children: a retrospective study using

Xinhua Cao, Xiaoyin Xu, S Ted Treves, Laura A Drubach, Neha Kwatra, Min Zhang, Frederic H Fahey, David A Diamond, Stephan D Voss

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xinhua CaoDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. xinhua.cao@childrens.harvard.edu.ORCID 0000-0002-7011-0171
Xiaoyin XuDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
S Ted TrevesDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Laura A DrubachDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Neha KwatraDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Min ZhangDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Frederic H FaheyDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
David A DiamondDepartment of Urology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Stephan D VossDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Boston Children's Hospital · USBrigham and Women's Hospital · US

Funding

Computer aided diagnosis of cancer metastases in the brainR01LM012434 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI YOUNG, GEOFFREY · 2016 to 2020
$2.9M
NLM NIH HHS R01 LM012434
6 · The paper itself

Abstract

backgroundBoth the development of kidney function in healthy children and autoregulation ability of kidney function in patients with asymmetric kidneys are important in clinical diagnosis and treatment of kidney-related diseases, but there are however only limited studies. This study aimed to investigate development of kidney function in normal children with healthy symmetric kidneys and autoregulation of the healthy kidney compensating the functional loss of a diseased one in children with asymmetric kidneys.

methodsTwo hundred thirty-seven children (156 male, 81 female) from 0 to 20y (average 4.6y ± 5.1) undergoing

resultsNo significant difference of MAG3 clearance (p = 0.723) was found between independent abnormal group and normal group. The autoregulation rate of kidney clearance in abnormal group was 94.2% on average, and no significant differences were found between two age groups (p = 0.49), male and female (p = 0.39), and left kidney and right kidney (p = 0.92) but two different grades of asymmetric kidneys (p = 0.02).

conclusionsThe healthy kidney of two asymmetric kidneys can automatically regulate total kidney function up to 94% of two symmetric kidneys in normal children.

Indexed as

Kidney DiseasesRadioisotope RenographyChildFemaleHomeostasisHumansKidneyMaleRadiopharmaceuticalsRetrospective StudiesTechnetium Tc 99m MertiatideRadiopharmaceuticalsTechnetium Tc 99m Mertiatide99mTc-MAG3AutoregulationKidney functionPediatricRenal developmentRenography

Identifiers

PMID35091836
OpenAlexW4210681414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.