Evidence map›Paper›PMID 35091821›Full record

ArticleDiabetologia2022

Adiponectin deficiency induces hepatic steatosis during pregnancy and gestational diabetes in mice.

Brittany L Moyce Gruber, Laura K Cole, Bo Xiang, Mario A Fonseca, Julianne Klein, Grant M Hatch, Christine A Doucette, Vernon W Dolinsky

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Brittany L Moyce GruberDepartment of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.
Laura K ColeDepartment of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.
Bo XiangDepartment of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.
Mario A FonsecaDepartment of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.
Julianne KleinDiagnostic Services of Manitoba, Winnipeg, MB, Canada.
Grant M HatchDepartment of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.
Christine A DoucetteDiabetes Research Envisioned and Accomplished in Manitoba (DREAM) Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Vernon W DolinskyDepartment of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada. vdolinsky@chrim.ca.
University of Manitoba · CAChildren's Hospital Research Institute of Manitoba · CADiagnostic Services Manitoba · CA

Funding

CIHR MOP 136885
6 · The paper itself

Abstract

aims/hypothesisObesity and hepatic steatosis are risk factors for gestational diabetes mellitus (GDM), a common complication of pregnancy. Adiponectin is a fat-derived hormone that improves hepatic steatosis and insulin sensitivity. Low levels of circulating adiponectin are associated with GDM development. We hypothesised that adiponectin deficiency causes fatty liver during pregnancy, contributing to the development of GDM.

methodsTo determine the role of adiponectin in fatty liver development during pregnancy, we compared pregnant (third week of pregnancy) adiponectin knockout (KO) mice (strain B6;129-Adipoq

resultsIn the third week of pregnancy, fasted pregnant adiponectin KO mice were hyperglycaemic on a low-fat diet (9.2 mmol/l vs 7.7 mmol/l in controls, p<0.05) and were glucose and pyruvate intolerant relative to wild-type mice. Pregnant adiponectin KO mice developed hepatic steatosis and a threefold elevation in hepatic triacylglycerols (p<0.05) relative to wild-type mice. Gestational weight gain and food consumption were similar in KO and wild-type mice. Adenoviral-mediated adiponectin supplementation to pregnant adiponectin KO mice improved glucose tolerance, prevented fasting hyperglycaemia and attenuated fatty liver development. CONCLUSIONS/

interpretationAdiponectin deficiency increased hepatic lipid accumulation during the period of pregnancy associated with increased fat utilisation. Consequently, adiponectin deficiency contributed to glucose intolerance, dysregulated gluconeogenesis and hyperglycaemia, all of which are characteristic of GDM. Increasing adiponectin in the last week of pregnancy alleviated hepatic steatosis and restored normal glucose homeostasis during pregnancy.

Indexed as

Diabetes, GestationalFatty LiverHyperglycemiaInsulin ResistanceAdiponectinAnimalsFemaleGlucoseHumansLiverMetabolism, Inborn ErrorsMiceMice, KnockoutPregnancyAdiponectinAdipoq protein, mouseGlucoseAdiponectinGestational diabetesGluconeogenesisHepatic steatosisHigh-fat dietInsulin resistanceNAFLDObesityPregnancy

Identifiers

PMID35091821
OpenAlexW4210621497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.