ArticlePediatric surgery international2022
Incidence and prognosis of thyroid cancer in children: based on the SEER database.
Article in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Age-specific risk of malignancy in pediatric thyroid cytology: Reframing ROM based on pre-test probability.The Journal of clinical endocrinology and metabolism · 2026Article
- Long-Term Outcomes of Patients Diagnosed With Differentiated Thyroid Cancer in Childhood and Young Adulthood.The Journal of clinical endocrinology and metabolism · 2026Article
- Toward Standardized Management of Indeterminate Thyroid Nodules in Pediatric Patients: A Systematic Review and Call for a Comprehensive Risk Stratification Model.Journal of clinical medicine · 2025Review
- The Impact of Radioactive Iodine on Outcomes Among Pediatric and Adolescent Thyroid Cancer Patients: A SEER Database Analysis.Cancers · 2025Article
- Article
- Risk factor analysis of childhood and adolescent thyroid cancer mediastinal lymph node and distant metastasis.Frontiers in oncology · 2025Article
- Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective.Life (Basel, Switzerland) · 2024Article
- Evolving approaches in paediatric thyroid cytopathology: A review.Cytopathology : official journal of the British Society for Clinical Cytology · 2024Review
- Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.Endocrine pathology · 2023Review
- The Prognostic Significance of BRAF Gene Analysis in Children and Adolescents with Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Long-term prognostic analysis of children and adolescents with differentiated thyroid carcinoma based on therapeutic response to initial radioiodine therapy.Frontiers in endocrinology · 2023Article
- Strategies for Radioiodine Treatment: What's New.Cancers · 2022Review
- Retrospective analysis of clinical characteristics and risk factors of differentiated thyroid cancer in children.Frontiers in pediatrics · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo update the recognition of the trends in the incidence of childhood thyroid cancer (TC) and its prognosis.
methodsA large-scale sample based on long time-line public database was recruited. Join-point regression model was used to analyze the incidence trend of childhood TC. Univariable and multivariable Cox regression model analyses were applied to explore the survival situation and prognostic factors.
resultsThe incidence rate of childhood TC increased between 1975 and 2016 from 3.8/million (95% CI 2.6-5.5) to 11.5/million (95% CI 9.2-14.1), AAPC = 2.38% (95% CI 1.98-9.65) and could be divided into two stages of increasing trends. The incidence rate of Trend1 (1975-2005) increased slowly (APC = 1.08%, 95% CI 0.38-1.82) while Trend2 (2005-2016) increased dramatically (APC = 6.77%, 95% CI 4.30-9.28). Annual incidence rate of small size tumor (< 4 cm) and local stage childhood TC increased significantly. The overall cumulative survival rate for childhood TC was high up to 97-99%. Males, black race, MTC type, distant metastasis, tumor size ≥ 4 cm, non-primary cancer were the independent risk factors of childhood TC prognosis.
conclusionA contribution of overdetection to rising pediatric TC rates might not be able to rule out. For clinical implications, screening TC in children with potential specific risk factors is feasible. Over-treatment to small size and local stage TC in children should be avoided.
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