Evidence map›Paper›PMID 35091681›Full record

ArticleOncogene2022

Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment.

James Saliba, Baptiste Coutaud, Kiran Makhani, Noam Epstein Roth, Jennie Jackson, Joo Yeoun Park, Natascha Gagnon, Paolo Costa, Thiviya Jeyakumar, Marina Bury and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Oncogene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  15. Article
  16. Identification roles of NFE2L3 in digestive system cancers.Journal of cancer research and clinical oncology · 2024
    Article
  17. Article
  18. New insight into the CNC-bZIP member, NFE2L3, in human diseases.Frontiers in cell and developmental biology · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

James SalibaLady Davis Institute for Medical Research, Montreal, Canada.ORCID http://orcid.org/0000-0003-0450-9616
Baptiste CoutaudLady Davis Institute for Medical Research, Montreal, Canada.
Kiran MakhaniLady Davis Institute for Medical Research, Montreal, Canada.
Noam Epstein RothLady Davis Institute for Medical Research, Montreal, Canada.
Jennie JacksonLady Davis Institute for Medical Research, Montreal, Canada.
Joo Yeoun ParkLady Davis Institute for Medical Research, Montreal, Canada.
Natascha GagnonLady Davis Institute for Medical Research, Montreal, Canada.
Paolo CostaLady Davis Institute for Medical Research, Montreal, Canada.
Thiviya JeyakumarGoodman Cancer Institute and Departments of Oncology, Biochemistry and Medicine, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-4647-555X
Marina BuryLady Davis Institute for Medical Research, Montreal, Canada.
Nicole BeaucheminGoodman Cancer Institute and Departments of Oncology, Biochemistry and Medicine, McGill University, Montreal, Quebec, Canada.
Koren K MannLady Davis Institute for Medical Research, Montreal, Canada.
Volker BlankLady Davis Institute for Medical Research, Montreal, Canada. volker.blank@mcgill.ca.ORCID http://orcid.org/0000-0002-7029-2462
Jewish General Hospital · CAMcGill University · CAUniversity of British Columbia · CA

Funding

CIHR MOP-97932CIHR PJT-152937
6 · The paper itself

Abstract

We investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer. Our studies revealed that Nfe2l3

Indexed as

Colorectal NeoplasmsTumor MicroenvironmentAnimalsBasic-Leucine Zipper Transcription FactorsForkhead Transcription FactorsHumansInflammationInterleukin-33MiceT-Lymphocytes, RegulatoryBasic-Leucine Zipper Transcription FactorsForkhead Transcription FactorsInterleukin-33NFE2L3 protein, human

Identifiers

PMID35091681
PMCPMC8913363
OpenAlexW4210526440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.