Evidence map›Paper›PMID 35091680›Full record

ArticleOncogene2022

Oncogenesis induced by combined Phf6 and Idh2 mutations through increased oncometabolites and impaired DNA repair.

Tsung-Chih Chen, Chi-Yuan Yao, Yu-Ren Chen, Chang-Tsu Yuan, Chien-Chin Lin, Yueh-Chwen Hsu, Po-Han Chuang, Chein-Jun Kao, Yi-Hung Li, Hsin-An Hou and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. PHF6 suppresses self-renewal of leukemic stem cells in AML.bioRxiv : the preprint server for biology · 2024
    Article
  5. Transgenic IDH2Oncogene · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tsung-Chih ChenDivision of Hematology/Medical Oncology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Chi-Yuan YaoGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yu-Ren ChenDepartment of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chang-Tsu YuanGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chien-Chin LinGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yueh-Chwen HsuDepartment of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Po-Han ChuangGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chein-Jun KaoDepartment of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yi-Hung LiDepartment of Animal Science, Chinese Culture University, Taipei, Taiwan.
Hsin-An HouDivision of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Wen-Chien ChouDepartment of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. wchou@ntu.edu.tw.ORCID http://orcid.org/0000-0003-2967-698X
Hwei-Fang TienDivision of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-1384-5593
National Taiwan University · TWNational Taiwan University Hospital · TWChinese Culture University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of acute leukemia involves interaction among genetic alterations. Mutations of IDH1/2 and PHF6 are common and co-exist in some patients of hematopoietic malignancies, but their cooperative effects remain unexplored. In this study, we addressed the question by characterizing the hematopoietic phenotypes of mice harboring neither, Phf6 knockout, Idh2 R172K, or combined mutations. We found that the combined Phf6

Indexed as

Leukemia, Myeloid, AcuteAnimalsCarcinogenesisCell Transformation, NeoplasticDNADNA RepairHumansIsocitrate DehydrogenaseMiceMutationRepressor ProteinsTranscription FactorsDNAIsocitrate Dehydrogenaseisocitrate dehydrogenase 2, mousePHF6 protein, humanPhf6 protein, mouseRepressor ProteinsTranscription Factors

Identifiers

PMID35091680
OpenAlexW4210571084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.