SynthesisTranslational psychiatry2022
Brain network dysfunctions in addiction: a meta-analysis of resting-state functional connectivity.
Synthesis in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- The Effects of Transcranial Magnetic Stimulation on Alcohol Craving, Efficacy, Emotion, and Cognitive Function in Patients With Alcohol Use Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.Brain and behavior · 2026Pooled it
- A systematic review and coordinate-based meta-analysis of resting-state fMRI in athletes from open and closed skills sports.Scientific reports · 2025Pooled it
- Relating Functional Connectivity and Alcohol Use Disorder: A Systematic Review and Derivation of Relevance Maps for Regions and Connections.Human brain mapping · 2025Pooled it
- Functional Neural Alterations in Pathological Internet Use: A Meta-Analysis of Neuroimaging Studies.Frontiers in neurology · 2022Pooled it
- Baclofen Modulates Neural Intrinsic Functional Connectivity in Treatment-Seeking Individuals With Alcohol Use Disorder.Alcohol, clinical & experimental research · 2026Trial
- Light Therapy Alleviates Addiction-Related Symptoms and Reshapes Habenula and Midbrain Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- Neural cue reactivity and intrinsic functional connectivity in individuals with alcohol use disorder following treatment with topiramate or naltrexone.Psychopharmacology · 2025Trial
- The effects of N-acetyl cysteine on intrinsic functional connectivity and neural alcohol cue reactivity in treatment-seeking individuals with alcohol use disorder: a preliminary study.Psychopharmacology · 2025Trial
- Validation of the Chinese Stress Sensitivity Inventory and Its Association With Internet Gaming Disorder Symptoms.Psychiatry investigation · 2026Article
- Optimizing brain functional-structural architecture with cTBS to reduce relapse in alcohol use disorder: a randomized controlled trial.Molecular psychiatry · 2026Article
- Association of HIV infection and alcohol use on resting-state functional connectivity and mental health in youth living with perinatal HIV.Research square · 2026Article
- Potentially traumatic events and substance use do not predict changes in resting state functional connectivity in early adolescence.NeuroImage · 2026Article
- The Phase-Amplitude Coupling Induced by Drug Cues in Individuals With Methamphetamine Use Disorder During Withdrawal.Brain and behavior · 2026Article
- Task-related differences in network connectivity and dynamics in people with severe opioid use disorder compared with healthy controls.Translational psychiatry · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Prefrontal-centered cortical alterations and network dysconnectivity in cocaine use disorder.Frontiers in psychiatry · 2026Article
- Learning Mechanisms in Alcohol Use Disorders.Addiction biology · 2026Review
- Investigating hierarchical control among functional networks disrupted by opioid use disorder using effective connectivity.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Focused Ultrasound Neuromodulation: Exploring a Novel Treatment for Severe Opioid Use Disorder.Biological psychiatry · 2025Article
- Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resting-state functional connectivity (rsFC) provides novel insights into variabilities in neural networks associated with the use of addictive drugs or with addictive behavioral repertoire. However, given the broad mix of inconsistent findings across studies, identifying specific consistent patterns of network abnormalities is warranted. Here we aimed at integrating rsFC abnormalities and systematically searching for large-scale functional brain networks in substance use disorder (SUD) and behavioral addictions (BA), through a coordinate-based meta-analysis of seed-based rsFC studies. A total of fifty-two studies are eligible in the meta-analysis, including 1911 SUD and BA patients and 1580 healthy controls. In addition, we performed multilevel kernel density analysis (MKDA) for the brain regions reliably involved in hyperconnectivity and hypoconnectivity in SUD and BA. Data from fifty-two studies showed that SUD was associated with putamen, caudate and middle frontal gyrus hyperconnectivity relative to healthy controls. Eight BA studies showed hyperconnectivity clusters within the putamen and medio-temporal lobe relative to healthy controls. Altered connectivity in salience or emotion-processing areas may be related to dysregulated affective and cognitive control-related networks, such as deficits in regulating elevated sensitivity to drug-related stimuli. These findings confirm that SUD and BA might be characterized by dysfunctions in specific brain networks, particularly those implicated in the core cognitive and affective functions. These findings might provide insight into the development of neural mechanistic biomarkers for SUD and BA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.