Evidence map›Paper›PMID 35091503›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Reproducibility of the Rod Photoreceptor Response Depends Critically on the Concentration of the Phosphodiesterase Effector Enzyme.

Ala Morshedian, Gabriela Sendek, Sze Yin Ng, Kimberly Boyd, Roxana A Radu, Mingyao Liu, Nikolai O Artemyev, Alapakkam P Sampath, Gordon L Fain

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ala MorshedianStein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-7000.
Gabriela SendekStein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-7000.
Sze Yin NgStein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-7000.
Kimberly BoydDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, 52242.
Roxana A RaduStein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-7000.
Mingyao LiuShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China, 200062.
Nikolai O ArtemyevDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, 52242.ORCID 0000-0002-5266-6854
Alapakkam P SampathStein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-7000.ORCID 0000-0002-0785-9577
Gordon L FainStein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-7000 gfain@ucla.edu.ORCID 0000-0002-9813-0342
Doheny Eye Institute · USUniversity of Iowa · USEast China Normal University · CNUniversity of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
PHYSIOLOGY OF PHOTORECEPTORSR01EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORDON Lee FAIN · 1985 to 2026
$9.9M
REGULATION OF ROD CYCLIC GMP PHOSPHODIESTERASER01EY010843 · NEI · UNIVERSITY OF IOWA · PI Nikolai O Artemyev · 1995 to 2026
$8.9M
Molecular Mechanisms of Photoreceptor AdaptationR01EY029817 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAMPATH, ALAPAKKAM P · 2019 to 2023
$2.1M
The Role of Complement in Recessive Stargardt DiseaseR01EY025002 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RADU, ROXANA A · 2015 to 2019
$1.9M
MOLECULAR GENETICS OF EARLY EYE DEVELOPMENTZ01EY000311 · NEI · NATIONAL EYE INSTITUTE · PI TOMAREV, STANISLAV I · 1996 to 2008
$941k
PHYSIOLOGY OF PHOTORECEPTORSR37EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FAIN, GORDON LEE · 1990 to 1999
–
Intramural NIH HHS Z01 EY000311NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY001844NEI NIH HHS R01 EY010843NEI NIH HHS R01 EY025002NEI NIH HHS R01 EY029817NEI NIH HHS R37 EY001844
6 · The paper itself

Abstract

The high sensitivity of night vision requires that rod photoreceptors reliably and reproducibly signal the absorption of single photons, a process that depends on tight regulation of intracellular cGMP concentration through the phototransduction cascade. Here in the mouse (Mus musculus), we studied a single-site

Indexed as

Cyclic GMPPhosphoric Diester HydrolasesAnimalsMiceReproducibility of ResultsRetinaRetinal Rod Photoreceptor CellsCyclic GMPPhosphoric Diester HydrolasesGAF A domainphosphodiesteraserod photoreceptorsensitivitysingle-photon responsetransduction

Identifiers

PMID35091503
PMCPMC8936574
OpenAlexW4210404935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.