ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 47 citations in OpenAlex.
- Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety.International journal of molecular sciences · 2026Review
- EEG-ECeG Coherence Mapping of Human Cerebro-cerebellar Projections: An Exploratory Study.Cerebellum (London, England) · 2026Article
- Cerebellar Electrical Activity as a Marker for Predicting Brain Health and Disease: A Review.Brain sciences · 2026Review
- Sleep Oscillations Across Cortical, Subcortical and Cerebellar Structures in Magnetoencephalography.The European journal of neuroscience · 2026Article
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- EEG Connectivity is an Objective Signature of Reduced Consciousness and Sleep Depth.Brain topography · 2025Article
- Application of Graph-Theoretic Methods Using ERP Components and Wavelet Coherence on Emotional and Cognitive EEG Data.Brain sciences · 2025Article
- The brain-body circuit mediates acute stress-induced antiinflammatory reflex in bacterial cystitis by suppressing ILC2 activation.JCI insight · 2025Article
- Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging.Cerebellum (London, England) · 2024Review
- Cerebellar Functions Beyond Movement and Learning.Annual review of neuroscience · 2024Review
- Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier.MedComm · 2024Review
- Purkinje cell dysfunction causes disrupted sleep in ataxic mice.Disease models & mechanisms · 2024Article
- The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- The brain in chronic insomnia and anxiety disorder: a combined structural and functional fMRI study.Frontiers in psychiatry · 2024Article
- Pontine Waves Accompanied by Short Hippocampal Sharp Wave-Ripples During Non-rapid Eye Movement Sleep.Sleep · 2023Article
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- What Is the Involvement of the Cerebellum During Sleep?Neurology · 2023Article
- Role of cerebellum in sleep-dependent memory processes.Frontiers in systems neuroscience · 2023Review
- The little brain and the seahorse: Cerebellar-hippocampal interactions.Frontiers in systems neuroscience · 2023Review
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During sleep, the widespread coordination of neuronal oscillations across both cortical and subcortical brain regions is thought to support various physiological functions. However, how sleep-related activity within the brain's largest sensorimotor structure, the cerebellum, is multiplexed with well-described sleep-related mechanisms in regions such as the hippocampus remains unknown. We therefore simultaneously recorded from the dorsal hippocampus and three distinct regions of the cerebellum (Crus I, lobule VI, and lobules II/III) in male mice during natural sleep. Local field potential (LFP) oscillations were found to be coordinated between these structures in a sleep stage-specific manner. During non-REM sleep, prominent δ frequency coherence was observed between lobule VI and hippocampus, whereas non-REM-associated hippocampal sharp-wave ripple activity evoked discrete LFP modulation in all recorded cerebellar regions, with the shortest latency effects in lobule VI. We also describe discrete phasic sharp potentials (PSPs), which synchronize across cerebellar regions and trigger sharp-wave ripple suppression. During REM, cerebellar δ phase significantly modulated hippocampal theta frequency, and this effect was greatest when PSPs were abundant. PSPs were phase-locked to cerebellar δ oscillation peak and hippocampal theta oscillation trough, respectively. Within all three cerebellar regions, prominent LFP oscillations were observed at both low (δ, <4 Hz) and very high frequencies (∼250 Hz) during non-REM and REM sleep. Intracerebellar cross-frequency analysis revealed that δ oscillations modulate those in the very high-frequency range. Together, these results reveal multiple candidate physiological mechanisms to support "offline," bidirectional interaction within distributed cerebello-hippocampal networks.
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