ArticleProceedings of the National Academy of Sciences of the United States of America2022
Sirt6 regulates lifespan in
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
–field-weighted citation impact
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Who cites it
33 citing papers in PubMed.
- Article
- Conserved Transcriptomic Signatures of Sirt6 Activity: A Cross-Species RNA-seq Meta-analysis.bioRxiv : the preprint server for biology · 2026Article
- Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress.bioRxiv : the preprint server for biology · 2026Article
- Evaluation of Molecular Responses and Longevity Markers inInternational journal of molecular sciences · 2026Article
- Genomic Insights into Local Adaptation and Evolutionary Trajectories ofBiomolecules · 2026Article
- 4-Galactosylkojibiose Extends the Lifespan ofNutrients · 2026Article
- Article
- Mechanistic Links Between the Gut Microbiome and Longevity Therapeutics.Biomedicines · 2026Review
- STUB1 stabilizes sirtuin 6 via K63-linked ubiquitination to promote NRF2 deacetylation for enhanced ferroptosis resistance after spinal cord injury.Burns & trauma · 2026Article
- Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration.Nature communications · 2025Article
- Sirt6 prevents the age-related decline of HProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Epigenetic Regulation of Aging and its Rejuvenation.MedComm · 2025Review
- Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice.Bone research · 2025Article
- The Fourth Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Article
- SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status.bioRxiv : the preprint server for biology · 2024Article
- Repair of genomic interstrand crosslinks.DNA repair · 2024Review
- Icaritin greatly attenuates β-amyloid-induced toxicity in vivo.CNS neuroscience & therapeutics · 2024Article
- Molecular hallmarks of ageing in amyotrophic lateral sclerosis.Cellular and molecular life sciences : CMLS · 2024Review
- Article
Corrections and comments
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Authors and funding
16 authors.
Jackson R TaylorDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.ORCID 0000-0003-0382-6716
Jason G WoodDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.ORCID 0000-0003-3349-4994
Evan MizerakDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Samuel HinthornDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.ORCID 0000-0001-6403-6852
Julianna LiuDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.ORCID 0000-0002-1250-1043
Matthew FinnDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.ORCID 0000-0003-2025-7500
Sarah GordonDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.ORCID 0000-0002-5342-0135
Louis ZingasDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Chengyi ChangDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Mark A KleinDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53726.ORCID 0000-0002-6782-8502
John M DenuDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53726.
Vera GorbunovaDepartment of Biology, University of Rochester, Rochester, NY 14627.
Andrei SeluanovDepartment of Biology, University of Rochester, Rochester, NY 14627.
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016.ORCID 0000-0001-5322-4946
John M SedivyDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Stephen L HelfandDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912; stephen_helfand@brown.edu.
Funding
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vadim N. Gladyshev · 2014 to 2026
$36.9MSomatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4MThe role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2MMECHANISMS OF REPLICATIVE SENESCENCE IN CELLSR01AG016694 · NIA · BROWN UNIVERSITY · PI SEDIVY, JOHN M · 1999 to 2024
$5.7MControl of Gene Expression and Life SpanR01AG024353 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HELFAND, STEPHEN L · 2004 to 2018
$5.5MRegulation of epigenome stability by SIRT6 during aging. Supplement: Does centenarian variant of SIRT6 or bowhead whale SIRT6 confer protection from Alzheimer's disease?R37AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2019 to 2026
$4.7MEffectors of cellular senescence statesR37AG016694 · NIA · BROWN UNIVERSITY · PI SEDIVY, JOHN M · 2009 to 2018
$3.2MThe effect of life span modifying interventions on Alzheimer's Disease in Drosophila and Mice.R01AG067306 · NIA · BROWN UNIVERSITY · PI HELFAND, STEPHEN L · 2020 to 2024
$2.9MControl of Gene Expression and Life SpanRF1AG024353 · NIA · BROWN UNIVERSITY · PI HELFAND, STEPHEN L · 2019 to 2019
$2.5MPredoctoral Training Program in Biological Data Science at Brown UniversityT32GM128596 · NIGMS · BROWN UNIVERSITY · PI RAMACHANDRAN, SOHINI, SANDSTEDE, BJORN · 2018 to 2022
$1.5MMechanisms of Lifespan Regulation by Sirt6 in Drosophila melanogasterK99AG057812 · NIA · BROWN UNIVERSITY · PI TAYLOR, JACKSON RICHARD · 2018 to 2021
$320kNIA NIH HHS K99 AG057812NIA NIH HHS P01 AG047200NIA NIH HHS P01 AG051449NIA NIH HHS R01 AG016694NIA NIH HHS R01 AG024353NIA NIH HHS R01 AG027237NIA NIH HHS R01 AG067306NIA NIH HHS R37 AG016694NIA NIH HHS R37 AG046320NIA NIH HHS RF1 AG024353NIGMS NIH HHS T32 GM128596
Abstract
Sirt6 is a multifunctional enzyme that regulates diverse cellular processes such as metabolism, DNA repair, and aging. Overexpressing Sirt6 extends lifespan in mice, but the underlying cellular mechanisms are unclear.
Indexed as
AgingAnimalsDrosophila melanogasterDrosophila ProteinsFemaleGene ExpressionGene Expression RegulationHaploinsufficiencyHistone DeacetylasesLongevityMaleSirtuinsDrosophila ProteinsHistone DeacetylasesSirtuinsaginghistonelifespanMycSirt6
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.