Evidence map›Paper›PMID 35090947›Full record

ArticleThe Journal of allergy and clinical immunology2022

Structural insights into MRGPRX2: A new vision of itch and allergy.

Anna M Trier, Brian S Kim

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Maladaptive immunity to the microbiota promotes neuronal hyperinnervation and itch via IL-17A.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Beyond the classic players: Mas-related G protein-coupled receptor member X2 role in pruritus and skin diseases.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Review
  4. Review
  5. Emerging concepts in neuropathic and neurogenic itch.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Review
  6. The structure, function, and pharmacology of MRGPRs.Trends in pharmacological sciences · 2023
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Anna M TrierDivision of Biology and Biomedical Sciences, Washington University School of Medicine, St Louis, Mo.
Brian S KimKimberly and Eric J. Waldman Department of Dermatology, Precision Immunology Institute, Friedman Brain Institute, Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: itchdoctor@mountsinai.org.

Funding

Neuroimmune Regulation of Atopic DermatitisR01AR070116 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2016 to 2021
$3.8M
Natural Killer Cell Regulation of Skin InflammationR01AR077007 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2021 to 2025
$2.5M
Innate Immune Regulation of Skin InflammationK08AR065577 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2014 to 2018
$711k
The Role of IL-33 in Chronic ItchR21AI167047 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KIM, BRIAN · 2021 to 2022
$460k
Epithelial Regulation of Chronic ItchF30AI154912 · NIAID · WASHINGTON UNIVERSITY · PI TRIER, ANNA MEREDITH · 2020 to 2021
$82k
NIAID NIH HHS F30 AI154912NIAID NIH HHS R21 AI167047NIAMS NIH HHS K08 AR065577NIAMS NIH HHS R01 AR070116NIAMS NIH HHS R01 AR077007
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HypersensitivityPruritusCell DegranulationHumansMast CellsNerve Tissue ProteinsReceptors, G-Protein-CoupledReceptors, NeuropeptideMRGPRX2 protein, humanNerve Tissue ProteinsReceptors, G-Protein-CoupledReceptors, NeuropeptideAllergycryogenic electron microscopyGPCRitchMrgprsMRGPRX2MRGPRX4prurituspseudoallergic

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.