Evidence map›Paper›PMID 35090899›Full record

ArticleBiophysical journal2022

Electrostatic Interactions between CSTF2 and pre-mRNA Drive Cleavage and Polyadenylation.

Elahe Masoumzadeh, Petar N Grozdanov, Anushka Jetly, Clinton C MacDonald, Michael P Latham

Open access · hybridAbstract read
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elahe MasoumzadehTexas Tech University, Lubbock, Texas.
Petar N GrozdanovTexas Tech University Health Sciences Center, Lubbock, Texas.
Anushka JetlyTexas Tech University, Lubbock, Texas.
Clinton C MacDonaldTexas Tech University Health Sciences Center, Lubbock, Texas.
Michael P LathamTexas Tech University, Lubbock, Texas. Electronic address: michael.latham@ttu.edu.
Texas Tech University · US

Funding

Structural Biology Studies of a Large DNA Repair ComplexR35GM128906 · NIGMS · UNIVERSITY OF MINNESOTA · PI Michael Parker Latham · 2018 to 2026
$3.1M
NIGMS NIH HHS R35 GM128906
6 · The paper itself

Abstract

Nascent pre-mRNA 3'-end cleavage and polyadenylation (C/P) involves numerous proteins that recognize multiple RNA elements. Human CSTF2 binds to a downstream U- or G/U-rich sequence through its RNA recognition motif (RRM) regulating C/P. We previously reported the only known disease-related CSTF2 RRM mutant (CSTF2

Indexed as

PolyadenylationRNA PrecursorsAnimalsMiceProtein BindingRNARNA Recognition MotifStatic ElectricityRNARNA Precursors

Identifiers

PMID35090899
PMCPMC8873925
OpenAlexW4210451676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.