Evidence map›Paper›PMID 35090799›Full record

ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2022

Sodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease.

William E Hughes, David P Treichler, Kenichi Ueda, Joshua M Bock, Darren P Casey

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01983826 (Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01983826 nacompletednot on this map

Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease

TypeinterventionalSponsorUniversity of IowaRan2013 to 2016Enrolled21ConditionsPeripheral Artery DiseaseArmsSodium Nitrate, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

William E HughesDepartments of Physical Therapy and Rehabilitation Science, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center University of Iowa, Iowa City, IA, USA.
David P TreichlerDepartments of Physical Therapy and Rehabilitation Science, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center University of Iowa, Iowa City, IA, USA.
Kenichi UedaAnesthesia, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center University of Iowa, Iowa City, IA, USA.
Joshua M BockDepartments of Physical Therapy and Rehabilitation Science, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center University of Iowa, Iowa City, IA, USA.
Darren P CaseyDepartments of Physical Therapy and Rehabilitation Science, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center University of Iowa, Iowa City, IA, USA. Electronic address: darren-casey@uiowa.edu.
University of Iowa · US

Funding

The University of Iowa Clinical and Translational Science AwardU54TR001356 · NCATS · UNIVERSITY OF IOWA · PI WINOKUR, PATRICIA · 2015 to 2016
$7.1M
NCATS NIH HHS U54 TR001356
6 · The paper itself

Abstract

BACKGROUND &

aimsPeripheral artery disease (PAD) is characterized by elevated blood pressure (BP), low nitric oxide availability (NO), and exaggerated pressor responses to sympatho-excitatory stressors. Inorganic nitrate reduces peripheral BP in healthy and chronically diseased populations. The objective of this study was to investigate the effects of eight-weeks of sodium nitrate (NaNO

methods21 patients with PAD were recruited to participate in this study, undergoing 8-weeks of NaNO

conclusionOur data suggest that eight-weeks of NaNO CLINICAL TRIALS REGISTRATION NUMBER: NCT01983826.

Indexed as

NitratesPeripheral Arterial DiseaseBlood PressureDietary SupplementsHumansNitratessodium nitrateBlood pressureInorganic nitrateNitric oxidePeripheral arterial disease

Identifiers

PMID35090799
PMCPMC8857030
OpenAlexW4200020780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.