ArticleAmerican journal of human genetics2022
Trans-ancestral fine-mapping of MHC reveals key amino acids associated with spontaneous clearance of hepatitis C in HLA-DQβ1.
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Article in American journal of human genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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5 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Targets of protective immunity and opportunities in hepatitis C virus vaccine development.Nature reviews. Immunology · 2026Review
- Identity by descent and local ancestry mapping of HCV spontaneous clearance in populations of diverse ancestries.BMC genomics · 2025Article
- Evidence for Pathogen-Driven Selection Acting onEcology and evolution · 2025Article
- Autoantibodies to apolipoprotein A-I in hepatitis C virus infection: a role in disease progression?Frontiers in immunology · 2025Article
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Authors and funding
33 authors at 14 institutions in 5 countries.
Ana ValenciaJohns Hopkins University, School of Medicine, Baltimore, MD 21205, USA; Universidad Pontificia Bolivariana, Medellín, Antioquia 050031, Colombia.
Candelaria VergaraJohns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Chloe L ThioJohns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Nicolas VinceUniversité de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes 44000, France.
Venceslas DouillardUniversité de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes 44000, France.
Alba GrifoniCenter for infectious Diseases and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Andrea L CoxJohns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Eric O JohnsonGenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC 27709, USA.
Alex H KralGenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC 27709, USA.
James J GoedertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Alessandra MangiaLiver Unit, Medical Sciences Department, Fondazione "Casa Sollievo della Sofferenza" IRCCS, 71013 San Giovanni Rotondo, Italy.
Valeria PiazzollaLiver Unit, Medical Sciences Department, Fondazione "Casa Sollievo della Sofferenza" IRCCS, 71013 San Giovanni Rotondo, Italy.
Shruti H MehtaJohns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Gregory D KirkJohns Hopkins University, School of Medicine, Baltimore, MD 21205, USA; Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Arthur Y KimDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Georg M LauerLiver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Raymond T ChungLiver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Jennifer C PriceDivision of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Francisco, CA 94143, USA.
Salim I KhakooUniversity of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
Laurent AlricInternal Medicine-Department of Digestive Diseases, Rangueil Hospital, Toulouse University, 1, 31400 Toulouse, France.
Matthew E CrampSouth West Liver Unit, Plymouth PL6 8DH, UK.
Sharyne M DonfieldRho, Inc., Durham, NC 27713, USA.
Brian R EdlinSUNY Downstate College of Medicine, Brooklyn, NY 11203, USA.
Michael P BuschUniversity of California San Francisco and Vitalant Research Institute, San Francisco, CA 94118, USA.
Graeme AlexanderUCL Institute for Liver and Digestive Health, The Royal Free Hospital, Pond St, Hampstead, London NW3 2QG, UK.
Hugo R RosenUniversity of Colorado, Aurora, CO 80045, USA.
Edward L MurphyUniversity of California San Francisco and Vitalant Research Institute, San Francisco, CA 94118, USA.
Genevieve L WojcikJohns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Pierre-Antoine GourraudUniversité de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes 44000, France.
Alessandro SetteCenter for infectious Diseases and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92093, USA.
David L ThomasJohns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Priya DuggalJohns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: pduggal@jhu.edu.
Johns Hopkins University · USHarvard University · USInserm · FRUniversity of California, San Francisco · USCasa Sollievo della Sofferenza · ITLa Jolla Institute for Immunology · USRTI International · USNational Institutes of Health · USRagon Institute of MGH, MIT and Harvard · USRho (United States) · USSouthampton General Hospital · GBSUNY Downstate Health Sciences University · USThe Royal Free Hospital · GBUniversity of Colorado Anschutz Medical Campus · US
Funding
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6MVirology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ARTHUR Y KIM · 2009 to 2026
$48.1MThe AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9MIMMUNE EPITOPE AND ANALYSIS PROGRAM: Transplantation of organs, tissues and cells 75N93019C00001 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI WILSON, STEPHEN · 2019 to 2025
$23.1MINCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERSR01DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 1999 to 2017
$15.5MHIV and Hepatitis C Pathogenesis & The Human GenomeR01DA013324 · NIDA · JOHNS HOPKINS UNIVERSITY · PI THOMAS, DAVID L · 1999 to 2018
$12.0MNATURAL HISTORY OF HIV INFECTION IN INJECTION DRUG USERSR37DA004334 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 1997 to 2006
$9.0MThe role of NK cells during acute HCV infection and antiviral therapyU19AI066345 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LAUER, GEORG MICHAEL · 2005 to 2014
$8.5MScientific CoreU19AI088791 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 2010 to 2020
$8.2MMolecular genetics and population studies of the KIR and HLA gene complexesZIABC010792 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$7.8MTHE NATURAL HISTORY OF HIV INFECTION AMONG DRUG USERSR01DA004334 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 1987 to 2011
$7.6MHuman Genetic determinants of HBV recoveryR01AI148049 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DUGGAL, PRIYA, THOMAS, DAVID L · 2020 to 2025
$4.7MCCR NIH HHS HHSN261200800001CMedical Research Council MR/S009388/1NCI NIH HHS HHSN261200800001ENCRR NIH HHS UL1 RR024996NHLBI NIH HHS R01 HL076902NIAID NIH HHS 75N93019C00001NIAID NIH HHS R01 AI148049NIAID NIH HHS R56 AI091649NIAID NIH HHS U01 AI131314NIAID NIH HHS U19 AI066345NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI088791NICHD NIH HHS R01 HD041224NIDA NIH HHS R01 DA004334NIDA NIH HHS R01 DA012568NIDA NIH HHS R01 DA013324NIDA NIH HHS R01 DA016159NIDA NIH HHS R01 DA021550NIDA NIH HHS R01 DA026141NIDA NIH HHS R01 DA033541NIDA NIH HHS R01 DA038632NIDA NIH HHS R37 DA004334NIDA NIH HHS R56 DA004334NIDA NIH HHS U01 DA036297
Abstract
Spontaneous clearance of acute hepatitis C virus (HCV) infection is associated with single nucleotide polymorphisms (SNPs) on the MHC class II. We fine-mapped the MHC region in European (n = 1,600; 594 HCV clearance/1,006 HCV persistence) and African (n = 1,869; 340 HCV clearance/1,529 HCV persistence) ancestry individuals and evaluated HCV peptide binding affinity of classical alleles. In both populations, HLA-DQβ1Leu26 (p value
Indexed as
Polymorphism, Single NucleotideAcute DiseaseAllelesAmino Acid SubstitutionBlack PeopleFemaleGene ExpressionGenome-Wide Association StudyGenotypeHepacivirusHepatitis CHLA-DQ beta-ChainsHost-Pathogen InteractionsHumansLeucineMaleHLA-DQB1 antigenHLA-DQ beta-ChainsLeucineProlineProtein Isoformsfine-mappingGWASHCV clearancehepatitis C virusHLA-DQβ1HLA imputationhost geneticsinfectionMHCtrans-ancestral
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.