ArticleImmunity2022
Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers.
Open access · greenAbstract read
In one paragraph
Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Revisiting down syndrome through the lens of interferonopathy and innate immune dysregulation.Frontiers in immunology · 2026Pooled it
- IgA2Cell reports. Medicine · 2025Trial
- A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.Immunity · 2026Article
- Expression patterns of CD24 and CD27 resolve the origins and gradual differentiation of CD11cThe EMBO journal · 2026Article
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Human Peripheral B Cell Subsets: Evolving notions about B cell biology and the broad relevance of B cells in disease.Immunological reviews · 2026Review
- Progressive deterioration of adaptive immune repertoires in Down syndrome linked to interferon hyperactivity and lymphoid tissue disorganization.bioRxiv : the preprint server for biology · 2026Article
- Uncovering ectopic GC-like niches for tumor reactive lymphocyte priming in lung adenocarcinoma using Stereo-XCR-seq.Nature communications · 2026Article
- SPEN Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities.Cancer discovery · 2026Article
- APOL1 risk alleles modulate T cell receptor signaling to promote allograft rejection.The Journal of clinical investigation · 2026Article
- The Developmental and Functional Implications of Age-Associated B Cells (ABCs) Across Tissue Microenvironments.Immunological reviews · 2026Review
- Interferon-Mediated Regulation of Memory B Cell Identity and Function.Immunological reviews · 2026Review
- Age-Associated B Cells: Origins, Regulation, and Tissue-Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases.Immunological reviews · 2026Review
- BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes.iScience · 2026Article
- Defective inducible T cell costimulator signalling drives neuropilin-1Experimental & molecular medicine · 2026Article
- Multiple roads to IgE memory: A pluralistic model of IgE immunity.Cell reports · 2026Review
- Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus.Nature reviews. Rheumatology · 2026Review
- Atypical memory B cell clonal expansion and inflammatory programs associate with platelet-activating antibody development in COVID-19.JCI insight · 2026Article
- Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.Journal for immunotherapy of cancer · 2026Review
- Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Wenzhi SongDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Olivia Q AntaoCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.
Emily CondiffDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Gina M SanchezCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.
Irene ChernovaDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Krzysztof ZembrzuskiCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.
Holly SteachDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Kira RubtsovaDepartment of Biomedical Research, National Jewish Health, Denver, CO, USA.
Davide AngelettiDepartment of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Alexander LemenzeCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.
Brian J LaidlawDivision of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Joe CraftDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address: joseph.craft@yale.edu.
Jason S WeinsteinCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address: jason.weinstein@rutgers.edu.
Rutgers, The State University of New Jersey · USYale University · USNational Jewish Health · USUniversity of Gothenburg · SEWashington University in St. Louis · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MIMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4MT cell regulation of pathogenic B cells in systemic autoimmunityR01AR073912 · NIAMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Jason Weinstein · 2018 to 2026
$3.2MMOLECULAR CHARACTERIZATION OF THE SNRNP POLYPEPTIDESR01AR040072 · NIAMS · YALE UNIVERSITY · PI Joseph Edgar Craft · 1990 to 2026
$2.5MFollicular Helper T Cell Function in AutoimmunityR01AR074545 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2019 to 2022
$1.3MTranscriptional Regulation of T Follicular Helper Cells in LupusK01AR067892 · NIAMS · YALE UNIVERSITY · PI WEINSTEIN, JASON · 2015 to 2019
$614kNCATS NIH HHS UL1 TR001863NIAMS NIH HHS K01 AR067892NIAMS NIH HHS R01 AR040072NIAMS NIH HHS R01 AR073912NIAMS NIH HHS R01 AR074545NIAMS NIH HHS R37 AR040072
Abstract
Tbet
Indexed as
AlphainfluenzavirusAnimalsAntibodies, ViralB-LymphocytesCD11 AntigensCell DifferentiationGerminal CenterIntegrinsLymphocyte SubsetsLymphocytic choriomeningitis virusMemory B CellsMiceSpleenT-Box Domain ProteinsT Follicular Helper CellsVirus DiseasesAntibodies, ViralCD11 AntigensIntegrinsItgax protein, mouseT-Box Domain Proteinsage-associated B cellsgerminal centerhumoral memoryTbet(+)CD11c(+) B cellsTfh cells
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.