Evidence map›Paper›PMID 35090535›Full record

Trial reportTrials2022

The ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery.

Hugh M Paterson, Seonaidh Cotton, John Norrie, Susan Nimmo, Irwin Foo, Angie Balfour, Doug Speake, Graeme MacLennan, Andrew Stoddart, Karen Innes and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07073846 (Efficacy of Lidocaine-Dexmedetomidine Combination Therapy in Reducing Post-Operative Pain, Inflammatory Response, and Oxidative Stress in Patients Undergoing Bariatric Surgery), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07073846 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Lidocaine-Dexmedetomidine Combination Therapy in Reducing Post-Operative Pain, Inflammatory Response, and Oxidative Stress in Patients Undergoing Bariatric Surgery

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2027Enrolled104ConditionsMorbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative AnalgesiaArmsIntravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia, 0.9 % Saline Placebo + Standard Anesthesia
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hugh M PatersonUniversity of Edinburgh, Edinburgh, UK.
Seonaidh CottonCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
John NorrieEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Susan NimmoAnaesthetics Department, Western General Hospital, Edinburgh, UK.
Irwin FooAnaesthetics Department, Western General Hospital, Edinburgh, UK.
Angie BalfourColorectal Surgery, Western General Hospital, Edinburgh, UK.
Doug SpeakeColorectal Surgery, Western General Hospital, Edinburgh, UK.
Graeme MacLennanCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
Andrew StoddartEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Karen InnesCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK. kareninnes@abdn.ac.uk.ORCID http://orcid.org/0000-0001-8512-4368
Sarah CameronCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
Lorna AucottCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
Kirsty McCormackCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
University of Aberdeen · GBWestern General Hospital · GBUniversity of Edinburgh · GB

Funding

Chief Scientist Office HSRU1Health Technology Assessment Programme 15/130/95
6 · The paper itself

Abstract

backgroundReturn of gastrointestinal (GI) function is fundamental to patient recovery after colorectal surgery and is required before patients can be discharged from hospital safely. Up to 40% of patients suffer delayed return of GI function after colorectal surgery, causing nausea, vomiting and abdominal discomfort, resulting in longer hospital stay. Small, randomised studies have suggested perioperative intravenous (IV) lidocaine, which has analgesic and anti-inflammatory effects, may accelerate return of GI function after colorectal surgery. The ALLEGRO trial is a pragmatic effectiveness study to assess the benefit of perioperative IV lidocaine in improving return of GI function after elective minimally invasive (laparoscopic or robotic) colorectal surgery.

methodsUnited Kingdom (UK) multi-centre double blind placebo-controlled randomised controlled trial in 562 patients undergoing elective minimally invasive colorectal resection. IV lidocaine or placebo will be infused for 6-12 h commencing at the start of surgery as an adjunct to usual analgesic/anaesthetic technique. The primary outcome will be return of GI function. DISCUSSION: A 6-12-h perioperative intravenous infusion of 2% lidocaine is a cheap addition to usual anaesthetic/analgesic practice in elective colorectal surgery with a low incidence of adverse side-effects. If successful in achieving quicker return of gut function for more patients, it would reduce the rate of postoperative ileus and reduce the duration of inpatient recovery, resulting in reduced pain and discomfort with faster recovery and discharge from hospital. Since colorectal surgery is a common procedure undertaken in every acute hospital in the UK, a reduced length of stay and reduced rate of postoperative ileus would accrue significant cost savings for the National Health Service (NHS).

trial registrationEudraCT Number 2017-003835-12; REC Number 17/WS/0210 the trial was prospectively registered (ISRCTN Number: ISRCTN52352431 ); date of registration 13 June 2018; date of enrolment of first participant 14 August 2018.

Indexed as

Colorectal SurgeryLidocaineAnesthetics, LocalCarbazolesHumansPostoperative PainState MedicineTryptaminesAnesthetics, LocalCarbazolesfrovatriptanLidocaineTryptaminesAnalgesiaColorectal surgeryGastrointestinalIleusIntravenous lidocaineMinimally invasive surgeryPainProtocolRCTRecovery

Identifiers

PMID35090535
PMCPMC8795946
OpenAlexW4210250527

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.