Evidence map›Paper›PMID 35090515›Full record

ArticleJournal of experimental & clinical cancer research : CR2022

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner.

Jiapeng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang, Dalin Zhang, Wenwu Dong, Liang Shao, Liang He, Xiaoyu Ji and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 1 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 1 synthesis or guideline pooled it, 195 citations in OpenAlex.

  1. Pooled it
  2. FTO-mediated mRNA biology · 2026
    Article
  3. Article
  4. Article
  5. NAT10-mediated acJournal of molecular histology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. NNature reviews. Cancer · 2026
    Review
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  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jiapeng HuangDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Wei SunDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Zhihong WangDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Chengzhou LvDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Ting ZhangDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Dalin ZhangDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Wenwu DongDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Liang ShaoDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Liang HeDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Xiaoyu JiDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Ping ZhangDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.
Hao ZhangDepartment of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China. haozhang@cmu.edu.cn.
First Hospital of China Medical University · CN

Funding

China Postdoctoral Science Foundation 2018M641739National Natural Science Foundation of China 81902726Natural Science Foundation of Education Bureau of Liaoning Province QNZR2020009Natural Science Foundation of Liaoning Province 2020-MS-186
6 · The paper itself

Abstract

backgroundN6-methyladenosine (m

methodsQuantitative real-time PCR (qRT-PCR), western blotting and immunohistochemistry were performed to explore the expression profile of FTO in PTC tissues and adjacent non-cancerous thyroid tissues. Effects of FTO on PTC glycolysis and growth were investigated through in vitro and in vivo experiments. Mechanism of FTO-mediated m

resultsFTO expression was significantly downregulated in PTC tissues. Functional analysis showed that FTO inhibited PTC glycolysis and growth. Further analyses were conducted to explore FTO-mediated m

conclusionFTO acts as a tumor suppressor to inhibit tumor glycolysis in PTC. The findings of the current study showed that FTO inhibited expression of APOE through IGF2BP2-mediated m

Indexed as

AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOApolipoproteins ECell Line, TumorCell ProliferationGlycolysisHumansPrognosisRNA, MessengerThyroid Cancer, PapillaryAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOApolipoproteins EFTO protein, humanN-methyladenosineRNA, MessengerAPOEFTOGlycolysisN6-methyladenosine (m6A)Papillary thyroid cancer (PTC)

Identifiers

PMID35090515
PMCPMC8796435
OpenAlexW4210813406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.