ArticleJournal of translational medicine2022
Moderate physical activity may not decrease the risk of cardiovascular disease in persistently overweight and obesity adults.
Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Machine learning for sudden cardiac death prediction among older adults using community-based electronic health records.BMC public health · 2025Article
- Physical activity, cardiovascular disease, and mortality across obesity levels.The EPMA journal · 2025Article
- Association between muscle strength and cardiometabolic multimorbidity risk among middle-aged and older Chinese adults: a nationwide longitudinal cohort study.BMC public health · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBody mass index (BMI) and physical activity (PA) has been documented to be associated with cardiovascular disease (CVD). However, the evidences regarding joint phenotypes of BMI and PA trajectories with risk for CVD and all-cause mortality are still limited.
methodsParticipants from the Kailuan Study, followed up during 2006-2019 were included, with primary outcomes of CVDs (myocardial infarction or stroke) and all-cause mortality. BMI and PA were repeatedly measured at least three times, and thus joint phenotypes trajectory groups were identified by group-based trajectory modeling. Cox proportional hazards models were used to examine the associations between trajectory groups and CVDs and all-cause mortality.
resultsTotally 88,141 (6 trajectories) and 89,736 participants (5 trajectories) were included in the final analyses relating trajectories to CVDs and all-cause mortality, respectively. Compared with persistent normal-weight with moderate PA group, participants were associated with increased risk of CVD in persistent overweight with moderate PA trajectory group (adjusted hazard ratio [aHR]: 1.31, 95% confidence interval [CI]: 1.22-1.41) and persistent obesity with moderate PA trajectory group (aHR: 1.55, 95% CI: 1.41-1.69). While the rising to overweight with moderate PA in normal-weight status with active PA (aHR: 0.72, 95% CI: 0.65-0.79), persistent overweight with moderate PA (aHR: 0.92, 95% CI: 0.87-0.97) and decline to normal-weight in overweight status with moderate PA (aHR: 0.73, 95% CI: 0.67-0.80) trajectories group were significantly associated with decreased all-cause mortality risk. The associations remained robust among stratifying by age and sex individuals and sensitive analysis.
conclusionsThe long-term trajectories analysis showed that moderate PA may not decrease the risk of CVD in persistently overweight and obesity adults.
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