ArticleBMC medicine2022
Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Microbiota composition of the female reproductive tract and miscarriage: a systematic review and meta-analysis.NPJ biofilms and microbiomes · 2026Pooled it
- Trial
- Efficacy of clindamycin and LACTIN-V for in vitro fertilization patients with vaginal dysbiosis: a randomised double-blind, placebo-controlled multicentre trial.Nature communications · 2025Trial
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- The Impact of First-Trimester Vaginal Microecology on Spontaneous Abortion: A Retrospective Cohort Study.Pathogens (Basel, Switzerland) · 2026Article
- Predicting Miscarriage Risk Based on Periodontal and Hematological Parameters Using Artificial Neural Network and XGBoost Models.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Harnessing the Vaginal Microbiome: A New Frontier in the Prevention of Sexually Transmitted Infections.Expert reviews in molecular medicine · 2026Review
- Characteristics of Exosomes and Microbiota in the Decidua of Patients With Early Pregnancy Loss and Their Impact on Trophoblast Cells.Molecular reproduction and development · 2026Article
- An Innovative Screening Panel for Preventing Miscarriages-Perspectives, Guidance and Guidelines.Antioxidants (Basel, Switzerland) · 2026Article
- Machine learning-based prediction of BV-relevant probiotic functional potential in vaginal-derived Lactobacillus crispatus strains.BMC microbiology · 2026Article
- Exploring the relationship between threatened abortion and vaginal microbiota: A retrospective study.Medicine · 2026Article
- Leveraging health records to identify diagnoses associated with recurrent pregnancy loss across two medical centers.iScience · 2026Article
- Targeting vaginal dysbiosis: prospects for the application of live biotherapeutics products.Frontiers in microbiology · 2026Review
- Multi-omics insights into immune tolerance at the maternal-fetal interface in recurrent pregnancy loss: mechanisms, integration challenges, and translational perspectives.Frontiers in immunology · 2026Review
- Multi-omics integration of the vaginal microbiome and inflammatory proteome for non-invasive prediction of infertility: a machine learning approach.Frontiers in cell and developmental biology · 2026Article
- How microbiota influence maternal blood disorder in miscarriage.Molecular biology reports · 2025Review
- Implication of the Vaginal Microbiome in Female Infertility and Assisted Conception Outcomes.Genomics, proteomics & bioinformatics · 2025Article
- Vaginal microbiome and recurrent pregnancy loss.Infection and immunity · 2025Review
- Correlation between Lactobacillus of Vaginal Microbiota and the Pregnancy Outcomes for Patients Experiencing Recurrent Miscarriage.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying mechanisms are poorly understood. We aim to investigate the vaginal microbial composition and the local immune response in chromosomally normal and abnormal miscarriages and compare this to uncomplicated pregnancies delivering at term.
methodsWe used 16S rRNA gene based metataxonomics to interrogate the vaginal microbiota in a cohort of 167 women, 93 miscarriages (54 euploid and 39 aneuploid using molecular cytogenetics) and 74 women who delivered at term and correlate this with the aneuploidy status of the miscarriages. We also measured the concentrations of IL-2, IL-4, IL-6, IL-8, TNF-α, IFN-γ, IL-1β, IL-18 and IL-10 in cervical vaginal fluid.
resultsWe show that euploid miscarriage is associated with a significantly higher prevalence of Lactobacillus spp. deplete vaginal microbial communities compared to aneuploid miscarriage (P = 0.01). Integration of matched cervicovaginal fluid immune-profiles showed that Lactobacillus spp. depleted vaginal microbiota associated with pro-inflammatory cytokine levels most strongly in euploid miscarriage compared to viable term pregnancy (IL-1β; P < 0.001, IL-8; P = 0.01, IL-6; P < 0.001).
conclusionsOur data suggest the vaginal microbiota plays an important aetiological role in euploid miscarriage and may represent a target to modify risk of pregnancy loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.