Evidence map›Paper›PMID 35089990›Full record

ArticlePhysical chemistry chemical physics : PCCP2022

Joint neutron/molecular dynamics vibrational spectroscopy reveals softening of HIV-1 protease upon binding of a tight inhibitor.

Daniel W Kneller, Oksana Gerlits, Luke L Daemen, Anna Pavlova, James C Gumbart, Yongqiang Cheng, Andrey Kovalevsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physical chemistry chemical physics : PCCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daniel W KnellerNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. kovalevskyay@ornl.gov.ORCID http://orcid.org/0000-0002-5416-5789
Oksana GerlitsDepartment of Natural Sciences, Tennessee Wesleyan University, Athens, TN 37303, USA.
Luke L DaemenNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. kovalevskyay@ornl.gov.
Anna PavlovaSchool of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA.
James C GumbartSchool of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID http://orcid.org/0000-0002-1510-7842
Yongqiang ChengNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. kovalevskyay@ornl.gov.
Andrey KovalevskyNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. kovalevskyay@ornl.gov.ORCID http://orcid.org/0000-0003-4459-9142
Oak Ridge National Laboratory · USGeorgia Institute of Technology · USTennessee Wesleyan College · US

Funding

Altering Hepatitis B Virus assembly through pharmacological interventionR01AI148740 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI GUMBART, JAMES C. · 2020 to 2024
$2.0M
NIAID NIH HHS R01 AI148740
6 · The paper itself

Abstract

Biomacromolecules are inherently dynamic, and their dynamics are interwoven into function. The fast collective vibrational dynamics in proteins occurs in the low picosecond timescale corresponding to frequencies of ∼5-50 cm

Indexed as

Molecular Dynamics SimulationVibrationHIV-1HIV ProteaseNeutronsSpectrum AnalysisHIV Proteasep16 protease, Human immunodeficiency virus 1

Identifiers

PMID35089990
PMCPMC8940534
OpenAlexW4206907085

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.