Evidence map›Paper›PMID 35089964›Full record

Trial reportPloS one2022

Intravenous Ringers lactate versus normal saline for predominantly mild acute pancreatitis in a Nepalese Tertiary Hospital.

Binod Karki, Suresh Thapa, Dibas Khadka, Sanjit Karki, Roshan Shrestha, Ajit Khanal, Ramila Shrestha, Bidhan Nidhi Paudel

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 6 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  11. Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Binod KarkiDepartment of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.ORCID 0000-0002-4650-9561
Suresh ThapaDepartment of Medicine, Pokhara Academy of Health Sciences, Pokhara, Nepal.
Dibas KhadkaGastroenterology Unit, Department of Medicine, National Academy of Medical Sciences, Kathmandu, Nepal.
Sanjit KarkiDepartment of Medicine, Patan Academy of Health Sciences, Lalitpur, Nepal.
Roshan ShresthaDepartment of Medicine, Patan Academy of Health Sciences, Lalitpur, Nepal.
Ajit KhanalGastroenterology Unit, Department of Medicine, National Academy of Medical Sciences, Kathmandu, Nepal.
Ramila ShresthaGastroenterology Unit, Department of Medicine, National Academy of Medical Sciences, Kathmandu, Nepal.
Bidhan Nidhi PaudelGastroenterology Unit, Department of Medicine, National Academy of Medical Sciences, Kathmandu, Nepal.
National Academy of Medical Sciences · NPPatan Academy of Health Sciences · NPNepalese Army Institute of Health Services · NPPokhara University · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute pancreatitis (AP) is a common presentation in patients admitted with acute abdomen. Whether Ringers lactate (RL) or Normal Saline (NS) as a resuscitation fluid is better still remains unclear. The aim of this study is to compare the efficacy of RL and NS in terms of control of systemic inflammation by measuring indirect markers specifically Systemic Inflammation Response Syndrome (SIRS) scores and C- Reactive Protein (CRP) level.

methodsThis was an open label randomized trial conducted in a tertiary level hospital of Nepal. Ethical approval was obtained prior to the study. Patients with acute pancreatitis were randomized to either RL or NS group for the fluid resuscitation. The fluid was given as per the study protocol for three days for hydration. Baseline SIRS and CRP were recorded on admission and subsequently as defined. All the data were analyzed using SPSS ver 20.0 software.

resultsTotal 51 patients were enrolled, 26 in RL and 25 in NS group. The commonest etiology of AP was alcohol (84.31%). SIRS was present in 46.2% and 64.0% of patients in RL and NS group respectively (p = 0.20) on admission. At least one SIRS criteria was still present in 44.0% of patients in the NS group compared to only 15.4% in the RL group after 24 hours (p = 0.025). The baseline CRP were comparable in both the groups. However after 72 hours, the increment of CRP was more in the NS group compared to the RL group; median value of 14.2 mg/dl (12.15, 16.45) and 22.2 mg/dl (18.20, 30.60) in RL and NS group respectively (p<0.001).

conclusionsRingers lactate was associated with a reduction in systemic inflammation compared to normal saline in patients with acute pancreatitis. Incidence of SIRS at 72 hours and occurrence of local complications were however similar in both the groups.

Indexed as

Administration, IntravenousAdultC-Reactive ProteinFemaleHumansMaleMiddle AgedNepalOutcome Assessment, Health CarePancreatitisRinger's LactateSaline SolutionSystemic Inflammatory Response SyndromeTertiary Care CentersYoung AdultC-Reactive ProteinRinger's LactateSaline Solution

Identifiers

PMID35089964
PMCPMC9126573
OpenAlexW4210443724

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.