ArticleIEEE transactions on medical imaging2022
High-Speed Balanced-Detection Visible-Light Optical Coherence Tomography in the Human Retina Using Subpixel Spectrometer Calibration.
Article in IEEE transactions on medical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Spectrometer matching for balanced detection in spectral-domain optical coherence tomography by autocorrelation minimization.Biomedical optics express · 2026Article
- OCT-guided angle-resolved low-coherence interferometry for microstructural analysis of the human retina.Biomedical optics express · 2026Article
- Spectroscopic correlation tomography (SpCT) for visualization of spatial correlations in volumetric OCT scans.Biomedical optics express · 2026Article
- Optical Coherence Tomography with Gapped Spectrum Using Sparse Iterative Covariance-Based Estimation.Sensors (Basel, Switzerland) · 2026Article
- Vis-OCT Explorer: an open-source software for visible-light optical coherence tomography data processing.Biomedical optics express · 2026Article
- Robotic Optical Coherence Tomography With Expanded Three-Dimensional Field-of-View Using Point-Cloud-Based Volumetric Montaging.IEEE transactions on medical imaging · 2025Article
- Spectroscopic analysis of volumetric OCT data for the automated measurement of scatterer size.Journal of the Optical Society of America. A, Optics, image science, and vision · 2025Article
- Analysis of pulsatile motion in the murine cornea using phase-sensitive visible-light optical coherence tomography.Biomedical optics express · 2025Article
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Integrated visible-light optical coherence tomography and fluorescence scanning laser ophthalmoscopy to image retinal ganglion cell axons.Biomedical optics express · 2025Article
- Balanced-detection visible optical coherence tomography with a low-noise supercontinuum laser.Biomedical optics express · 2025Article
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Visible light polarization-sensitive optical coherence tomography with balanced detection.Journal of biomedical optics · 2025Article
- The Perspective of Using Optical Coherence Tomography in Ophthalmology: Present and Future Applications.Diagnostics (Basel, Switzerland) · 2025Review
- Development of next generation low-cost OCT towards improved point-of-care retinal imaging.Biomedical optics express · 2025Article
- Review
- Article
- Longitudinal imaging of vitreal hyperreflective foci in mice with acute optic nerve damage using visible-light optical coherence tomography.Optics letters · 2024Article
- Adaptive balanced detection spectral domain optical coherence tomography.Biomedical optics express · 2023Article
- Longitudinal Observation of Retinal Response to Optic Nerve Transection in Rats Using Visible Light Optical Coherence Tomography.Investigative ophthalmology & visual science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Increases in speed and sensitivity enabled rapid clinical adoption of optical coherence tomography (OCT) in ophthalmology. Recently, visible-light OCT (vis-OCT) achieved ultrahigh axial resolution, improved tissue contrast, and provided new functional imaging capabilities, demonstrating the potential to improve clinical care further. However, limited speed and sensitivity caused by the high relative intensity noise (RIN) in supercontinuum lasers impeded the clinical adoption of vis-OCT. To overcome these limitations, we developed balanced-detection vis-OCT (BD-vis-OCT), which uses two calibrated spectrometers to cancel RIN and other noises. We analyzed the RIN to achieve robust subpixel calibration between the two spectrometers and showed that BD-vis-OCT reduced the A-line noise floor by up to 20.5 dB. Metrics comparing signal-to-noise-ratios showed similar image qualities across multiple reference arm powers, a hallmark of operation near the shot-noise limit. We imaged healthy human retinas at an A-line rate of 125 kHz and a field-of-view up to 10 mm ×4 mm. We found that BD-vis-OCT revealed retinal anatomical features previously obscured by the noise floor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.