Evidence map›Paper›PMID 35089808›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Faster skin wound healing predicts survival after myocardial infarction.

Mediha Becirovic-Agic, Upendra Chalise, Mira Jung, Jocelyn R Rodriguez-Paar, Shelby R Konfrst, Elizabeth R Flynn, Jeffrey D Salomon, Michael E Hall, Merry L Lindsey

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Cellular and molecular signals of cardiac wound healing after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  2. Guidelines on the use of sex and gender in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Mediha Becirovic-AgicUniversity of Nebraska Medical Center, Omaha, Nebraska.
Upendra ChaliseUniversity of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0002-7798-7697
Mira JungInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.
Jocelyn R Rodriguez-PaarUniversity of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0003-3599-7392
Shelby R KonfrstUniversity of Nebraska Medical Center, Omaha, Nebraska.
Elizabeth R FlynnDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Jeffrey D SalomonUniversity of Nebraska Medical Center, Omaha, Nebraska.
Michael E HallDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-5733-1025
Merry L LindseyUniversity of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0002-4090-0391
VA Nebraska Western Iowa Health Care System · USJackson Memorial Hospital · USMedizinische Hochschule Hannover · DEUniversity of Mississippi Medical Center · USUniversity of Nebraska Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GUDA, CHITTIBABU · 2016 to 2025
$42.8M
MMP-12 as an Endogenous Post-MI Resolution Promoting FactorR01HL137319 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LINDSEY, MERRY L. · 2019 to 2022
$1.5M
BLRD VA I01 BX000505NHLBI NIH HHS R01 HL137319NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

Both skin wound healing and the cardiac response to myocardial infarction (MI) progress through similar pathways involving inflammation, resolution, tissue repair, and scar formation. Due to the similarities, we hypothesized that the healing response to skin wounding would predict future response to MI. Mice were given a 3-mm skin wound using a disposable biopsy punch and the skin wound was imaged daily until closure. The same set of animals was given MI by permanent coronary artery ligation 28 days later and followed for 7 days. Cardiac physiology was measured by echocardiography at baseline and MI

Indexed as

Myocardial InfarctionVentricular RemodelingAnimalsHumansInflammationMacroglobulinsMaleMiceMice, Inbred C57BLMyocardiumTranscription FactorsWound HealingEAF1 protein, humanMacroglobulinsTranscription Factorsheart failureinflammationmyocardial infarctionremodeling

Identifiers

PMID35089808
PMCPMC8917917
OpenAlexW4210482857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.