Evidence map›Paper›PMID 35089807›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

FoxO4 controls sGCβ transcription in vascular smooth muscle.

Joseph C Galley, Megan P Miller, Subramaniam Sanker, Mingjun Liu, Iraida Sharina, Emil Martin, Delphine Gomez, Adam C Straub

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. The Impact of Single Nucleotide Polymorphisms and Other Mechanisms on Aspirin Resistance.Cardiovascular & hematological disorders drug targets · 2025
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joseph C GalleyHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-3463-8390
Megan P MillerHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
Subramaniam SankerDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-5038-5485
Mingjun LiuHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
Iraida SharinaDepartment of Cardiovascular Medicine, University of Texas Health Science Center, Houston, Texas.
Emil MartinDepartment of Cardiovascular Medicine, University of Texas Health Science Center, Houston, Texas.
Delphine GomezHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
Adam C StraubHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-0542-9466
University of Pittsburgh · USThe University of Texas Health Science Center at Houston · US

Funding

Epigenetic control of smooth muscle cell phenotype during microvascular remodelingR01HL146465 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Delphine Gomez · 2019 to 2026
$3.4M
PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM008424 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 1994 to 2019
$3.4M
Vascular Smooth Muscle and Blood Pressure Regulation By Cyb5R3²R01HL128304 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRAUB, ADAM CARL · 2016 to 2020
$2.4M
Role of Xanthine Oxidase in Heme-induced Vascular DysfunctionR01HL153532 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELLEY, ERIC EUGENE, STRAUB, ADAM CARL · 2021 to 2024
$2.1M
Type II Alveolar Redox Control in Fibrogenesis and ResolutionR01HL149825 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORA, ANA LUCIA, STRAUB, ADAM CARL · 2020 to 2023
$2.1M
Investigating the role of FoxO transcriptional regulation of sGC in smooth muscleF31HL151173 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GALLEY, JOSEPH CARL · 2020 to 2022
$138k
HHS | National Institutes of Health (NIH) GM008424HHS | National Institutes of Health (NIH) HL128304HHS | National Institutes of Health (NIH) HL133864HHS | National Institutes of Health (NIH) HL146465HHS | National Institutes of Health (NIH) HL149825HHS | National Institutes of Health (NIH) HL153532NHLBI NIH HHS F31 HL151173NHLBI NIH HHS R01 HL128304NHLBI NIH HHS R01 HL146465NHLBI NIH HHS R01 HL149825NHLBI NIH HHS R01 HL153532NIGMS NIH HHS T32 GM008424
6 · The paper itself

Abstract

Nitric oxide (NO) binds soluble guanylyl cyclase β (sGCβ) to produce cGMP and relax vascular smooth muscle cells (SMCs) needed for vasodilation. Although the regulation of NO-stimulated sGC activity has been well characterized at the posttranslational level, the mechanisms that govern sGC transcription remain incompletely understood. Recently, we identified Forkhead box subclass O (FoxO) transcription factors as essential for expression of sGC; however, the specific FoxO family member responsible for the expression of sGCβ in SMC remains unknown. Using FoxO shRNA knockdown adenovirus treatment in rat aortic SMCs, we show that FoxO1 or FoxO3 knockdown causes greater than twofold increases in

Indexed as

AnimalsAortaCells, CulturedForkhead Transcription FactorsMuscle, Smooth, VascularMyocytes, Smooth MuscleRatsSoluble Guanylyl CyclaseForkhead Transcription FactorsFOXO4 protein, ratGucy1a1 protein, ratGucy1b1 protein, ratSoluble Guanylyl CyclasecGMPFoxOnitric oxidesoluble guanylyl cyclasetranscription

Identifiers

PMID35089807
PMCPMC8873033
OpenAlexW4210248587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.