Evidence map›Paper›PMID 35089784›Full record

ArticleScience advances2022

Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals.

Antonio Torres-Méndez, Sinziana Pop, Sophie Bonnal, Isabel Almudi, Alida Avola, Ruairí J V Roberts, Chiara Paolantoni, Ana Alcaina-Caro, Ane Martín-Anduaga, Irmgard U Haussmann and 7 more

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
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  9. Article
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  11. Article
  12. Coupling of alternative splicing and alternative polyadenylation.Acta biochimica et biophysica Sinica · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Understanding species-specific and conserved RNA-protein interactionsbioRxiv : the preprint server for biology · 2024
    Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Antonio Torres-MéndezCentre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain.ORCID 0000-0002-1241-8629
Sinziana PopFrancis Crick Institute, London, UK.ORCID 0000-0002-8811-8307
Sophie BonnalCentre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain.ORCID 0000-0001-6096-3042
Isabel AlmudiCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain.ORCID 0000-0001-7978-4394
Alida AvolaFrancis Crick Institute, London, UK.
Ruairí J V RobertsFrancis Crick Institute, London, UK.ORCID 0000-0003-2216-1465
Chiara PaolantoniCenter for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.
Ana Alcaina-CaroCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain.ORCID 0000-0002-7352-5890
Ane Martín-AnduagaBiology Department, Brandeis University, Waltham, MA, USA.ORCID 0000-0003-2447-2195
Irmgard U HaussmannDepartment of Life Science, School of Health Sciences, Birmingham City University, Birmingham B5 3TN, UK.ORCID 0000-0002-2764-694X
Violeta MorinInstitute of Molecular Biology (IMB), Mainz, Germany.
Fernando CasaresCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain.ORCID 0000-0002-2181-3858
Matthias SollerSchool of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.ORCID 0000-0003-3844-0258
Sebastian KadenerBiology Department, Brandeis University, Waltham, MA, USA.
Jean-Yves RoignantCenter for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0003-1395-2150
Lucia Prieto-GodinoFrancis Crick Institute, London, UK.ORCID 0000-0002-2980-362X
Manuel IrimiaCentre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain.ORCID 0000-0002-2179-2567

Funding

Unraveling regulatory functions of circRNAs at the muscleblind locusR01GM124406 · NIGMS · BRANDEIS UNIVERSITY · PI Sebastian Kadener · 2017 to 2026
$2.4M
Characterizing a new role for timeless in the generation of robust and plastic circadian rhythmsR01GM125859 · NIGMS · BRANDEIS UNIVERSITY · PI KADENER, SEBASTIAN · 2019 to 2022
$1.6M
Mechanisms underlying disruption of intestinal epithelial barrier in critical illnessR01GM122406 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2017 to 2018
$594k
NIGMS NIH HHS R01 GM122406NIGMS NIH HHS R01 GM124406NIGMS NIH HHS R01 GM125859Wellcome Trust FC001594
6 · The paper itself

Abstract

Alternative splicing increases neuronal transcriptomic complexity throughout animal phylogeny. To delve into the mechanisms controlling the assembly and evolution of this regulatory layer, we characterized the neuronal microexon program in

Indexed as

Drosophila ProteinsRNA SplicingAlternative SplicingAnimalsDrosophilaMammalsMiceNerve Tissue ProteinsNeuronsRNA-Binding ProteinsDrosophila Proteinsfne protein, DrosophilaNerve Tissue ProteinsRNA-Binding Proteins

Identifiers

PMID35089784
PMCPMC8797185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.