Evidence map›Paper›PMID 35089687›Full record

ArticleAnalytical chemistry2022

Combining Isotopologue Workflows and Simultaneous Multidimensional Separations to Detect, Identify, and Validate Metabolites in Untargeted Analyses.

James N Dodds, Lingjue Wang, Gary J Patti, Erin S Baker

Abstract read
In one paragraph

Article in Analytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James N DoddsDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0002-9702-2294
Lingjue WangDepartment of Chemistry, Center for Metabolomics and Isotope Tracing, Washington University, St. Louis, Missouri, 63130, United States.
Gary J PattiDepartments of Chemistry and Medicine, Siteman Cancer Center, Center for Metabolomics and Isotope Tracing, Washington University, St. Louis, Missouri 63130, United States.ORCID 0000-0002-3748-6193
Erin S BakerDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0001-5246-2213

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Thomas Joseph McDonald · 2017 to 2026
$21.2M
Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Andrew R. Binder · 2015 to 2026
$18.3M
Uncovering the Mechanisms of PFAS-induced ImmunotoxicityP42ES031009 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PLANCHART, ANTONIO J. · 2020 to 2024
$9.3M
Developing Metabolomic Technologies to Advance Environmental Exposure AnalysisR35ES028365 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2017 to 2024
$5.9M
NIDDK NIH HHS P30 DK056341NIEHS NIH HHS P30 ES025128NIEHS NIH HHS P42 ES027704NIEHS NIH HHS P42 ES031009NIEHS NIH HHS R35 ES028365
6 · The paper itself

Abstract

While the combination of liquid chromatography and tandem mass spectrometry (LC-MS/MS) is commonly used for feature annotation in untargeted omics experiments, ensuring these prioritized features originate from endogenous metabolism remains challenging. Isotopologue workflows, such as isotopic ratio outlier analysis (IROA), mass isotopomer ratio analysis of U-

Indexed as

Ion Mobility SpectrometryTandem Mass SpectrometryChromatography, LiquidMetabolomicsWorkflow

Identifiers

PMID35089687
PMCPMC8934380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.