Evidence map›Paper›PMID 35089650›Full record

SynthesisInternational forum of allergy & rhinology2022

Cystic Fibrosis Foundation otolaryngology care multidisciplinary consensus recommendations.

Adam J Kimple, Brent A Senior, Edward T Naureckas, David A Gudis, Ted Meyer, Sarah E Hempstead, Helaine E Resnick, Dana Albon, Wayne Barfield, Margo McKenna Benoit and 21 more

Open access · bronzeAbstract readSystematic ReviewConsensus Statement
In one paragraph

Synthesis in International forum of allergy & rhinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Observational
  6. Review
  7. Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Observational
  17. Red ginseng aqueous extract improves mucociliary transport dysfunction and histopathology in CF rat airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 1 country.

Adam J KimpleDepartment of Otolaryngology/Head & Neck Surgery, The University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0003-1670-8401
Brent A SeniorDepartment of Otolaryngology/Head & Neck Surgery, The University of North Carolina, Chapel Hill, North Carolina, USA.
Edward T NaureckasDepartment of Pulmonary Medicine, Critical Care Medicine, University of Chicago Medicine, Chicago, Illinois, USA.
David A GudisDepartment of Otolaryngology - Head and Neck Surgery, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York, New York, USA.ORCID 0000-0002-1938-9349
Ted MeyerDepartment of Otolaryngology/Head & Neck Surgery, The University of North Carolina, Chapel Hill, North Carolina, USA.
Sarah E HempsteadCystic Fibrosis Foundation, Bethesda, Maryland, USA.
Helaine E ResnickResnick, Chodorow & Associates, USA.
Dana AlbonDepartment of Internal Medicine, Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, Virginia, USA.
Wayne BarfieldPediatric and Adult CF Center, Medical University of South Carolina, South Carolina, USA.
Margo McKenna BenoitDepartment of Otolaryngology-Head and Neck Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Daniel M BeswickDepartment of Head and Neck Surgery, University of California, Los Angeles, California, USA.ORCID 0000-0001-8612-5442
Eliza CallardCommunity Advisor to the Cystic Fibrosis Foundation, Bethesda, Maryland, USA.
Shelagh CoferMayo Clinic-Otolaryngology (ENT)/Head and Neck Surgery, Rochester, Minnesota, USA.
Veronica DownerMichigan Medicine, University of Michigan, Michigan, USA.
E Claire ElsonDepartment of Pharmacy, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Angela GarinisOregon Hearing Research Center, Oregon Health & Science University, Portland, Oregon, USA.
Ashleigh HaldermanDepartment of Otolaryngology/Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Lisa HamburgerCommunity Advisor to the Cystic Fibrosis Foundation, Bethesda, Maryland, USA.
Meagan HelmickCommunity Advisor to the Cystic Fibrosis Foundation, Bethesda, Maryland, USA.ORCID 0000-0003-1422-8295
Michael McCownDepartment of Pediatrics, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Cameron J McKinzieDepartment of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina, USA.
Hanna PhanCollege of Pharmacy, Department of Clinical Pharmacy, The University of Michigan, C.S. Mott Children's Hospital, Michigan Medicine, Michigan, USA.
Kenneth RodriguezDepartment of Otolaryngology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Ronald C RubensteinAllergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Ashley SeverinDepartment of Social Work, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Gopi ShahDepartment of Otolaryngology/Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ambika ShenoyDepartment of Pediatrics, Division of Pediatric Pulmonology, Nemours Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA.
Brittney SprouseDepartment of Pediatrics, Division of Pediatric Pulmonology, Nemours Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA.
Frank VirginDepartment of Otolaryngology - Head and Neck Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
Bradford A WoodworthDepartment of Otolaryngology - Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-3292-9167
Stella E LeeBrigham and Women's Hospital, Division of Otolaryngology-Head & Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Cystic Fibrosis Foundation · USUniversity of North Carolina at Chapel Hill · USAlfred I. duPont Hospital for Children · USChildren's Mercy Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Michigan · USArrow International (United States) · USBrigham and Women's Hospital · USMayo Clinic · USMedical University of South Carolina · USMonroe Carell Jr. Children's Hospital · USNewYork–Presbyterian Hospital · USOregon Health & Science University · USUniversity Hospitals of Cleveland · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of Chicago · USUniversity of Rochester Medical Center · USUniversity of Virginia · USWalter Reed National Military Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCystic fibrosis (CF) is a multisystem disease that often requires otolaryngology care. Individuals with CF commonly have chronic rhinosinusitis but also present with hearing loss and dysphonia. Given these manifestations of CF, otolaryngologists are frequently involved in the care of patients with CF; however, there is limited consensus on optimal management of sinonasal, otologic, and laryngologic symptoms.

methodsThe Cystic Fibrosis Foundation convened a multidisciplinary team of otolaryngologists, pulmonologists, audiologists, pharmacists, a social worker, a nurse coordinator, a respiratory therapist, two adults with CF, and a caregiver of a child with CF to develop consensus recommendations. Workgroups developed draft recommendation statements based on a systematic literature review, and a ≥80% consensus was required for acceptance of each recommendation statement.

resultsThe committee voted on 25 statements. Eleven statements were adopted recommending a treatment or intervention, while five statements were formulated recommending against a specific treatment or intervention. The committee recommended eight statements as an option for select patients in certain circumstances, and one statement did not reach consensus.

conclusionThese multidisciplinary consensus recommendations will help providers navigate decisions related to otolaryngology consultation, medical and surgical management of CF-CRS, hearing, and voice in individuals with CF. A collaborative and multidisciplinary approach is advocated to best care for our patients with CF. Future clinical research is needed utilizing standardized, validated outcomes with comprehensive reporting of patient outcome, effects of modulator therapies, and genetic characteristics to help continue to advance care, decrease morbidity, and improve the quality of life for individuals with CF.

Indexed as

Cystic FibrosisOtolaryngologySinusitisAdultChildHumansQuality of Lifechronic rhinosinusitiscystic fibrosisdysphoniaevidence-based medicineFESSsinusvoice and allergy

Identifiers

PMID35089650
PMCPMC9545592
OpenAlexW4210326370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.