ArticleHuman brain mapping2022
Enduring effect of abuse: Childhood maltreatment links to altered theory of mind network among adults.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Adverse childhood experiences and resting state functional connectivity of the triple brain network: a meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- The multimodal neuroimaging signatures and gene expression profiles for adverse childhood experiences.BMC medicine · 2025Pooled it
- Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis.Psychological medicine · 2023Pooled it
- Neural substrates of reward anticipation and outcome in schizophrenia: a meta-analysis of fMRI findings in the monetary incentive delay task.Translational psychiatry · 2022Pooled it
- Childhood maltreatment impacts the activity of the neural empathy but not theory of mind network: findings from a transdiagnostic sample.European archives of psychiatry and clinical neuroscience · 2026Article
- Regional and interregional brain functional abnormalities in major depressive disorder with childhood maltreatment.BMC psychiatry · 2025Article
- Family history, inflammation, and cerebellum in major depression: a combined VBM and dynamic functional connectivity study.Translational psychiatry · 2025Article
- Exploring the neural link between childhood maltreatment and depression: a default mode network rs-fMRI study.Frontiers in psychiatry · 2024Article
- Structural and functional changes in drug-naïve benign childhood epilepsy with centrotemporal spikes and their associated gene expression profiles.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The effects of childhood maltreatment on adolescent non-suicidal self-injury behavior: mediating role of impulsivity.Frontiers in psychiatry · 2023Article
- Different functional connectivity optimal frequency in autism compared with healthy controls and the relationship with social communication deficits: Evidence from gene expression and behavior symptom analyses.Human brain mapping · 2023Article
- Prediction of childhood maltreatment and subtypes with personalized functional connectome of large-scale brain networks.Human brain mapping · 2022Article
- Enduring effect of abuse: Childhood maltreatment links to altered theory of mind network among adults.Human brain mapping · 2022Article
- Aberrant static and dynamic functional connectivity of amygdala subregions in patients with major depressive disorder and childhood maltreatment.NeuroImage. Clinical · 2022Article
- Altered functional association and couplings: Effective diagnostic neuromarkers for Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- The functional connectivity of the middle frontal cortex predicts ketamine's outcome in major depressive disorder.Frontiers in neuroscience · 2022Article
Corrections and comments
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14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood maltreatment (CM) confers a great risk of maladaptive development outcomes later in life, however, the neurobiological mechanism underlying this vulnerability is still unclear. The present study aimed to investigate the long-term consequences of CM on neural connectivity while controlling for psychiatric conditions, medication, and, substance abuse. A sample including adults with (n = 40) and without CM (n = 50) completed Childhood Trauma Questionnaire (CTQ), personality questionnaires, and resting-state functional magnetic resonance imaging scan were recruited for the current study. The whole-brain functional connectivity (FC) was evaluated using an unbiased, data-driven, multivariate pattern analysis method. Relative to controls, adults with CM suffered a higher level of temperament and impulsivity and showed decreased FC between the insula and superior temporal gyrus (STG) and between inferior parietal lobule (IPL) and middle frontal gyrus, STG, and dorsal anterior cingulate cortex (dACC), while increased FC between IPL and cuneus and superior frontal gyrus (SFG) regions. The FCs of IPL with dACC and SFG were correlated with the anxious and cyclothymic temperament and attentional impulsivity. Moreover, these FCs partially mediated the relationship between CM and attentional impulsivity. Our results suggest that CM has a significant effect on the modulation of FC within theory of mind (ToM) network even decades later in adulthood, and inform a new framework to account for how CM results in the development of impulsivity. The novel findings reveal the neurobiological consequences of CM and provide new clues to the prevention and intervention strategy to reduce the risk of the development of psychopathology.
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