Evidence map›Paper›PMID 35089437›Full record

ArticleCellular and molecular life sciences : CMLS2022

A20 undermines alternative NF-κB activity and expression of anti-apoptotic genes in Helicobacter pylori infection.

Michelle C C Lim, Gunter Maubach, Anna M Birkl-Toeglhofer, Johannes Haybaeck, Michael Vieth, Mchael Naumann

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Advances inOncology letters · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Michelle C C LimInstitute of Experimental Internal Medicine, Otto Von Guericke University, Magdeburg, Germany.
Gunter MaubachInstitute of Experimental Internal Medicine, Otto Von Guericke University, Magdeburg, Germany.
Anna M Birkl-ToeglhoferInstitute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria.
Johannes HaybaeckInstitute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria.
Michael ViethInstitute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, Klinikum Bayreuth, Bayreuth, Germany.
Mchael NaumannInstitute of Experimental Internal Medicine, Otto Von Guericke University, Magdeburg, Germany. Naumann@med.ovgu.de.ORCID http://orcid.org/0000-0002-8060-2313
Otto-von-Guericke-Universität Magdeburg · DEInnsbruck Medical University · ATBayreuth Medical Center · DE

Funding

Deutsche Forschungsgemeinschaft SFB 854 (A04) 97850925
6 · The paper itself

Abstract

A hallmark of infection by the pathogen Helicobacter pylori, which colonizes the human gastric epithelium, is the simultaneous activation of the classical and alternative nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways, underlying inflammation and cell survival. Here, we report that the classical NF-κB target gene product A20 contributes to the negative regulation of alternative NF-κB signaling in gastric epithelial cells infected by H. pylori. Mechanistically, the de novo synthesized A20 protein interacts with tumor necrosis factor receptor-associated factor-interacting protein with forkhead-associated domain (TIFA) and thereby interferes with the association of TIFA with the NIK regulatory complex. We also show that alternative NF-κB activity contributes to the up-regulation of anti-apoptotic genes, such as baculoviral IAP repeat containing 2 (BIRC2), BIRC3 and B-cell lymphoma 2-related protein A1 (BCL2A1) in gastric epithelial cells. Furthermore, the observed over-expression of RelB in human gastric biopsies with type B gastritis and RelB-dependent suppression of apoptotic cell death emphasize an important role of the alternative NF-κB pathway in H. pylori infection.

Indexed as

Apoptosis Regulatory ProteinsBaculoviral IAP Repeat-Containing 3 ProteinCell Line, TumorGastric MucosaGastritisGene ExpressionGene Knockout TechniquesHelicobacter InfectionsHelicobacter pyloriHost-Pathogen InteractionsHumansMinor Histocompatibility AntigensNF-kappa BProto-Oncogene Proteins c-bcl-2Signal TransductionTranscription Factor RelAApoptosis Regulatory ProteinsBaculoviral IAP Repeat-Containing 3 ProteinBCL2-related protein A1BIRC3 protein, humanMinor Histocompatibility AntigensNF-kappa BProto-Oncogene Proteins c-bcl-2RELA protein, humanRELB protein, humanTNFAIP3 protein, humanTranscription Factor RelATranscription Factor RelBTumor Necrosis Factor alpha-Induced Protein 3ADP-heptoseLTα1β2NIKp100RelBTIFA

Identifiers

PMID35089437
PMCPMC8799570
OpenAlexW4210331973

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.