Evidence map›Paper›PMID 35089415›Full record

ArticleDie Ophthalmologie2022

[Ocular manifestations in patients with COVID-19].

Kristin Hösel, Claus von der Burchard, Domagoj Schunk, Jeanette Franzenburg, Thomas Bahmer, Derk Frank, Justina Dargvainiene, Johann B Roider

Open access · hybridAbstract read
In one paragraph

Article in Die Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. The relationship between retinal vascular tortuosity and retinal vasculitis.Journal of ophthalmic inflammation and infection · 2025
    Article
  2. Atypical presentation of acute macular neuroretinopathy: a case description.Quantitative imaging in medicine and surgery · 2025
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kristin HöselKlinik für Augenheilkunde, UKSH Kiel, Arnold-Heller-Str. 3, 24104, Kiel, Deutschland. kristin.hoesel@uksh.de.ORCID http://orcid.org/0000-0003-3399-4411
Claus von der BurchardKlinik für Augenheilkunde, UKSH Kiel, Arnold-Heller-Str. 3, 24104, Kiel, Deutschland.
Domagoj SchunkDepartment of Internal Medicine, UKSH Kiel, Kiel, Deutschland.
Jeanette FranzenburgDepartment of Clinical Chemistry, UKSH Kiel, Kiel, Deutschland.
Thomas BahmerDepartment of Internal Medicine, UKSH Kiel, Kiel, Deutschland.
Derk FrankDepartment of Internal Medicine, UKSH Kiel, Kiel, Deutschland.
Justina DargvainieneDepartment of Clinical Chemistry, UKSH Kiel, Kiel, Deutschland.
Johann B RoiderKlinik für Augenheilkunde, UKSH Kiel, Arnold-Heller-Str. 3, 24104, Kiel, Deutschland.
Christian-Albrechts-Universität zu Kiel · DEGerman Centre for Cardiovascular Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are only few reports on ocular symptoms and manifestations in association with coronavirus disease 2019 (COVID-19).

objectiveThe aim of this study is to describe ocular manifestations in the anterior and posterior segments of the eye and to analyze viral prevalence in tears of patients with COVID-19.

methodsHospitalized COVID-19 patients treated from 16 April 2020 to 7 January 2021 at this hospital were screened for ocular manifestations in the anterior and posterior segments. Conjunctival swabs were analyzed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA.

resultsA total of 37 patients were enrolled in this study. In the anterior segment we found chemosis of the conjunctiva (5), hyposphagma (2) and conjunctivitis (1). In 11 patients vascular alterations and potentially disease-specific manifestations of the fundus were found in one or both eyes: retinal hemorrhages (5), cotton wool spots (5) and tortuosity (5). One patient demonstrated branch artery occlusion, one had branch retinal vein occlusion and two patients had positive conjunctival swab results in one or both eyes.

conclusionOur findings of the anterior segment are commonly known, although not specific for COVID-19. Various vascular fundus abnormalities were found in the study; however, it is unclear whether these were correlated to systemic comorbidities or whether they were caused or exacerbated by COVID-19. This study suggests that the risk of viral transmission via tears is low.

Indexed as

COVID-19ConjunctivaHumansRNA, ViralSARS-CoV-2TearsRNA, ViralRetinal manifestationsSARS-CoV-2Transmission via tearsVascular alterationsViral shedding

Identifiers

PMID35089415
PMCPMC8796747
OpenAlexW4210357669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.