Evidence map›Paper›PMID 35089332›Full record

ReviewBriefings in bioinformatics2022

Multimodal deep learning for biomedical data fusion: a review.

Sören Richard Stahlschmidt, Benjamin Ulfenborg, Jane Synnergren

Registry-linked trialAbstract readReview
In one paragraph

Review in Briefings in bioinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07073430 (Application Evaluation Research on the Artificial Intelligence-assisted Support System for the Diagnosis of Colorectal Tubular Adenoma Lesions), which is not on this map. Cited by 262 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
262citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07073430 recruitingnot on this mapstarted 2023, after this paper: background citation

Application Evaluation Research on the Artificial Intelligence-assisted Support System for the Diagnosis of Colorectal Tubular Adenoma Lesions

TypeobservationalSponsorRenmin Hospital of Wuhan UniversityRan2023 to 2026Enrolled4,000ConditionsColorectal Adenoma, Artificial Intelligence (AI)ArmsAI models with NBI
3 · Its place in the literature

Who cites it

262 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Review
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  7. Review
  8. Observational
  9. [Advances in deep learning multimodal fusion for early diagnosis of knee osteoarthritis].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
  10. Review
  11. Article
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  13. Review
  14. Unifying multimodal single-cell data with a mixture-of-expertsbioRxiv : the preprint server for biology · 2026
    Article
  15. Article
  16. Wearable Flexible Sensors for Cardiovascular Disease Monitoring.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  17. Review
  18. Article
  19. Article
  20. Article

202 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sören Richard StahlschmidtSystems Biology Research Center, University of Skövde, Sweden.
Benjamin UlfenborgSystems Biology Research Center, University of Skövde, Sweden.
Jane SynnergrenSystems Biology Research Center, University of Skövde, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomedical data are becoming increasingly multimodal and thereby capture the underlying complex relationships among biological processes. Deep learning (DL)-based data fusion strategies are a popular approach for modeling these nonlinear relationships. Therefore, we review the current state-of-the-art of such methods and propose a detailed taxonomy that facilitates more informed choices of fusion strategies for biomedical applications, as well as research on novel methods. By doing so, we find that deep fusion strategies often outperform unimodal and shallow approaches. Additionally, the proposed subcategories of fusion strategies show different advantages and drawbacks. The review of current methods has shown that, especially for intermediate fusion strategies, joint representation learning is the preferred approach as it effectively models the complex interactions of different levels of biological organization. Finally, we note that gradual fusion, based on prior biological knowledge or on search strategies, is a promising future research path. Similarly, utilizing transfer learning might overcome sample size limitations of multimodal data sets. As these data sets become increasingly available, multimodal DL approaches present the opportunity to train holistic models that can learn the complex regulatory dynamics behind health and disease.

Indexed as

Deep Learningdata integrationdeep neural networksfusion strategiesmultimodal machine learningmulti-omicsrepresentation learning

Identifiers

PMID35089332
PMCPMC8921642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.