In one paragraphArticle in Journal of veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors at 1 institution in 1 country.
Xinyu WangHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0003-2151-9824 Yue WuHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0002-6748-9440 Lin LiuHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0002-9500-4762 Hui BaiHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0002-9013-7873 Zhiheng ZhangHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0002-9838-4350 Mingchao ZhaoHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0002-2408-8591 Tianwen MaHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0003-3809-1131 Xiaopeng SongHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0003-4881-3935 Lina JiaHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0003-3493-2992 Liangyu LvHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0001-7395-2756 Yue YuHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0002-1954-7327 Xinyu XuHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0002-5040-0171 Hong ChenHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China.ORCID https://orcid.org/0000-0002-1638-5369 Li GaoHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agriculture University, Harbin, Heilongjiang 150000, China. gaoli43450@163.com.ORCID https://orcid.org/0000-0001-9190-0562 Northeast Agricultural University · CN
Funding
National Key Research and Development Program of China 2017YFD0501601-2National Natural Science Foundation of China 31372491National Natural Science Foundation of China 31572580
6 · The paper itselfAbstract
backgroundXylazole (Xyl) is a veterinary anesthetic that is structurally and functionally similar to xylazine. However, the effects of Xyl in vitro remain unknown.
objectivesThis study aimed to investigate the anesthetic mechanism of Xyl using fetal rat nerve cells treated with Xyl.
methodsFetal rat nerve cells cultured for seven days were treated with 10, 20, 30, and 40 μg/ mL Xyl for 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min. Variations of amino acid neurotransmitters (AANTs), Nitric oxide-Cyclic GMP (NO-cGMP) signaling pathway, and ATPase were evaluated.
resultsXyl decreased the levels of cGMP and NO in nerve cells. Furthermore, Xyl affected the AANT content and Na
conclusionsThis study provided new evidence that the anesthetic and analgesic effects of Xyl are related to the inhibition of the NO-cGMP signaling pathway.
Indexed as
Cyclic GMPNitric OxideAdenosine TriphosphatasesAnimalsAnimals, NewbornCells, CulturedNeuronsRatsSignal TransductionThiazolesAdenosine TriphosphatasesCyclic GMPNitric OxideThiazolesxylazoleanesthesiacyclic GMPgamma-aminobutyric acidglutamic acidXylazole
Identifiers
PMID35088953
PMCPMC8799944
OpenAlexW4200613415
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
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